String theory has had a profound influence on research in Calabi-Yau spaces over the past twenty-five years. We first briefly mention some of the work in Khler Calabi-Yau manifolds that was influenced by the discovery of mirror symmetry in the late 1980s. We then discuss some of the mathematical motivations behind the recent work on non-Khler Calabi-Yau manifolds, which arise in string compactifications with fluxes. After extending mirror symmetry to non-Khler Calabi-Yau manifolds, we show how this leads to new cohomologies and invariants of non-Khler symplectic manifolds.

One great challenge of genomic research is to efficiently and accurately identify complex gene regulatory networks. The development of high-throughput technologies provides numerous experimental data such as DNA sequences, protein sequence, and RNA expression profiles makes it possible to study interactions and regulations among genes or other substance in an organism. However, it is crucial to make inference of genetic regulatory networks from gene expression profiles and protein interaction data for systems biology. This study will develop a new approach to reconstruct time delay Boolean networks as a tool for exploring biological pathways. In the inference strategy, we will compare all pairs of input genes in those basic relationships by their corresponding -scores for every output gene. Then, we will combine those consistent relationships to reveal the most probable relationship and reconstruct the genetic network. Specifically, we will prove that state transition pairs are sufficient and necessary to reconstruct the time delay Boolean network of nodes with high accuracy if the number of input genes to each gene is bounded. We also have implemented this method on simulated and empirical yeast gene expression data sets. The test results show that this proposed method is extensible for realistic networks.

We propose a novel method to apply Teichmller space theory to study the signature of a family of nonintersecting closed 3D curves on a general genus zero closed surface. Our algorithm provides an efficient method to encode both global surface and local contour shape information. The signatureTeichmller shape descriptoris computed by surface Ricci flow method, which is equivalent to solving an elliptic partial differential equation on surfaces and is numerically stable. We propose to apply the new signature to analyze abnormalities in brain cortical morphometry. Experimental results with 3D MRI data from Alzheimers disease neuroimaging initiative (ADNI) dataset [152 healthy control subjects versus 169 Alzheimers disease (AD) patients] demonstrate the effectiveness of our method and illustrate its potential as a novel surface-based cortical morphometry measurement in AD research.

We study Hawking radiation from three-dimensional black holes. For this purpose the emission of charged scalar and charged fermionic particles is investigated from charged BTZ black holes, with and without rotation. We use the quantum tunneling approach incorporating WKB approximation and spacetime symmetries. Another class of black holes which is asymptotic to a Sol three-manifold has also been investigated. This procedure gives us the tunneling probability of outgoing particles, and we compute the temperature of the radiation for these black holes. We also consider the quantum tunneling of particles from black hole asymptotic to Sol geometry.

In this paper we introduce a path complex that can be regarded as a generalization of the notion of a simplicial complex. The main motivation for considering path complexes comes from directed graphs (digraphs). We obtain a new notion of the path homology and cohomology of a digraph.