We prove that for any free ergodic probability measure-preserving action $${\mathbb{F}_n \curvearrowright (X, \mu)}$$ of a free group on$n$generators $${\mathbb{F}_n, 2\leq n \leq \infty}$$ , the associated group measure space II_{1}factor $${L^\infty (X)\rtimes \mathbb{F}_n}$$ has$L$^{∞}($X$) as its unique Cartan subalgebra, up to unitary conjugacy. We deduce that group measure space II_{1}factors arising from actions of free groups with different number of generators are never isomorphic. We actually prove unique Cartan decomposition results for II_{1}factors arising from arbitrary actions of a much larger family of groups, including all free products of amenable groups and their direct products.