This simple question does not have a simple answer. The boundary of such an interdisciplinary area is always moot and any attempt to give a formal definition is unlikely to be successful. Broadly speaking, financial econometrics is to study quantitative problems arising from finance. It uses statistical techniques and economic theory to address a variety of problems from finance. These include building financial models, estimation and inferences of financial models, volatility estimation, risk management, testing financial economics theory, capital asset pricing, derivative pricing, portfolio allocation, risk-adjusted returns, simulating financial systems, hedging strategies, among others. Technological invention and trade globalization have brought us into a new era of financial markets. Over the last three decades, enormous number of new financial products have been created to meet customers demands. For example, to reduce the impact of the fluctuations of currency exchange rates on a firms finance, which makes its profit more predictable and competitive, a multinational corporation may decide to buy the options on the future of foreign exchanges; to reduce the risk of price fluctuations of a commodity (eg lumbers, corns, soybeans), a farmer may enter into the future contracts of the commodity; to reduce the risk of weather exposures, amuse parks (too hot or too cold reduces the number of visitors) and energy companies may decide to purchase the financial derivatives based on the temperature. An important milestone is that in the year 1973, the worlds first options exchange opened in Chicago. At the very same year, Black and Scholes (1973

In the event-related functional magnetic resonance imaging (fMRI) data analysis, there is an extensive interest in accurately and robustly estimating the hemodynamic response function (HRF) and its associated statistics (eg, the magnitude and duration of the activation). Most methods to date are developed in the time domain and they have utilized almost exclusively the temporal information of fMRI data without accounting for the spatial information. The aim of this paper is to develop a multiscale adaptive smoothing model (MASM) in the frequency domain by integrating the spatial and temporal information to adaptively and accurately estimate HRFs pertaining to each stimulus sequence across all voxels in a three-dimensional (3D) volume. We use two sets of simulation studies and a real data set to examine the finite sample performance of MASM in estimating HRFs. Our real and simulated data analyses confirm

Large-scale multiple testing with correlated and heavy-tailed data arises in a wide range of research areas from genomics, medical imaging to finance. Conventional methods for estimating the false discovery proportion (FDP) often ignore the effect of heavy-tailedness and the dependence structure among test statistics, and thus may lead to inefficient or even inconsistent estimation. Also, the commonly imposed joint normality assumption is arguably too stringent for many applications. To address these challenges, in this article we propose a factor-adjusted robust multiple testing (FarmTest) procedure for large-scale simultaneous inference with control of the FDP. We demonstrate that robust factor adjustments are extremely important in both controlling the FDP and improving the power. We identify general conditions under which the proposed method produces consistent estimate of the FDP. As a byproduct that is

Maximum likelihood ratio theory contributes tremendous success to parametric inferences, due to the fundamental theory of Wilks (1938). Yet, there is no general applicable approach for nonparametric inferences based on function estimation. Maximum likelihood ratio test statistics in general may not exist in nonparametric function estimation setting. Even if they exist, they are hard to nd and can not be optimal as shown in this paper. In this paper, we introduce the sieve likelihood statistics to overcome the drawbacks of nonparametric maximum likelihood ratio statistics. New Wilks' phenomenon is unveiled. We demonstrate that the sieve likelihood statistics are asymptotically distribution free and follow 2-distributions under null hypotheses for a number of useful hypotheses and a variety of useful models including Gaussian white noise models, nonparametric regression models, varying coefficient models and generalized varying coefficient models. We further demonstrate that sieve likelihood ratio statistics are asymptotically optimal in the sense that they achieve optimal rates of convergence given by Ingster (1993). They can even be adaptively optimal in the sense of Spokoiny (1996) by using a simple choice of adaptive smoothing parameter. Our work indicates that the sieve likelihood ratio statistics are indeed general and powerful for nonparametric inferences based on function estimation.

In this chapter, we give a selective review of the nonparametric modeling methods using Cox's type of models in survival analysis. We first introduce Cox's model (Cox 1972) and then study its variants in the direction of smoothing. The model fitting, variable selection, and hypothesis testing problems are addressed. A number of topics worthy of further study are given throughout this chapter.