Over time, a population acquires neutral genetic substitutions as a consequence of random drift. A famous result in population genetics asserts that the rate, K, at which these substitutions accumulate in the population coincides with the mutation rate, u, at which they arise in individuals: K = u. This identity enables genetic sequence data to be used as a “molecular clock” to estimate the timing of evolutionary events. While the molecular clock is known to be perturbed by selection, it is thought that K = u holds very generally for neutral evolution. Here we show that asymmetric spatial population structure can alter the molecular clock rate for neutral mutations, leading to either K<u or K>u. Our results apply to a general class of haploid, asexually reproducing, spatially structured populations. Deviations from K = u occur because mutations arise unequally at different sites and have different probabilities of fixation depending on where they arise. If birth rates are uniform across sites, then K
u. In general, K can take any value between 0 and Nu. Our model can be applied to a variety of population structures. In one example, we investigate the accumulation of genetic mutations in the small intestine. In another application, we analyze over 900 Twitter networks to study the effect of network topology on the fixation of neutral innovations in social evolution.

The entropy is one of the fundamental states of a fluid and, in the viscous case, the equation that it satisfies is highly singular in the region close to the vacuum. In spite of its importance in the gas dynamics, the mathematical analyses on the behavior of the entropy near the vacuum region, were rarely carried out; in particular, in the presence of vacuum, either at the far field or at some isolated interior points, it was unknown whether the entropy remains its boundedness. The results obtained in this paper indicate that the ideal gases retain their uniform boundedness of the entropy, locally or globally in time, if the vacuum occurs at the far field only and the density decays slowly enough at the far field. Precisely, we consider the Cauchy problem to the one-dimensional full compressible Navier-Stokes equations without heat conduction, and establish the local and global existence and uniqueness of entropy-bounded solutions, in the presence of vacuum at the far field only. It is also shown that, different from the case that with compactly supported initial density, the compressible Navier-Stokes equations, with slowly decaying initial density, can propagate the regularities in inhomogeneous Sobolev spaces.

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It is known that finitely generated FI-modules over a field of characteristic 0 are Noetherian. We generalize this result to the abstract setting of an infinite EI category satisfying certain combinatorial conditions.