Adult stem cells, which exist throughout the body, multiply by cell division to replenish dying cells or to promote regeneration to repair damaged tissues. To perform these functions during the lifetime of organs or tissues, stem cells need to maintain their populations in a faithful distribution of their epigenetic states, which are suscepti- ble to stochastic fluctuations during each cell division, unexpected injury, and potential genetic mutations that occur during many cell divisions. However, it remains unclear how the three processes of differentiation, proliferation, and apoptosis in regulating stem cells collectively manage these challenging tasks. Here, without consid- ering molecular details, we propose a genetic optimal control model for adult stem cell regeneration that includes the three fundamental processes, along with cell division and adaptation based on differ- ential fitnesses of phenotypes. In the model, stem cells with a distri- bution of epigenetic states are required to maximize expected performance after each cell division. We show that heteroge- neous proliferation that depends on the epigenetic states of stem cells can improve the maintenance of stem cell distributions to create balanced populations. A control strategy during each cell division leads to a feedback mechanism involving heterogeneous proliferation that can accelerate regeneration with less fluctuation in the stem cell population. When mutation is allowed, apoptosis evolves to maximize the performance during homeostasis after multiple cell divisions. The overall results highlight the importance of cross-talk between genetic and epigenetic regulation and the performance objectives during homeostasis in shaping a desirable heterogeneous distribution of stem cells in epigenetic states.

In 1979, G. Parisi predicted a variational formula for the thermodynamic limit of the free energy in the Sherrington-Kirkpatrick model and described the role played by its minimizer. This formula was verified in the seminal work of Talagrand and later generalized to the mixed p-spin models by Panchenko. In this paper, we prove that the minimizer in Parisi's formula is unique at any temperature and external field by establishing the strict convexity of the Parisi functional.

We introduce an Alexander polynomial for MOY graphs. For a framed trivalent MOY graph G, we refine the construction and obtain a framed ambient isotopy invariant \Delta(G,c)(t). The invariant \Delta(G,c)(t) satisfies a series of relations, which we call MOY type relations, and conversely these relations determine \Delta(G,c)(t). Using them we provide a graphical definition of the Alexander polynomial of a link. Finally, we discuss some properties and applications of our invariants.

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We study different classes of Jensen measures for plurisubharmonic functions, in particular the relation between Jensen measures for continuous functions and Jensen measures for upper bounded functions. We prove an approximation theorem for plurisubharmonic functions in$B$-regular domain. This theorem implies that the two classes of Jensen measures coincide in$B$-regular domains. Conversely we show that if Jensen measures for continuous functions are the same as Jensen measures for upper bounded functions and the domain is hyperconvex, the domain satisfies the same approximation theorem as above.