Surface registration between cortical surfaces is crucial in medical imaging for performing systematic comparisons between brains. Landmark-matching registration that matches anatomical features, called the sulcal landmarks, is often required to obtain a meaningful 1-1 correspondence between brain surfaces. This is commonly done by parameterizing the surface onto a simple parameter domain, such as the unit sphere, in which the sulcal landmarks are consistently aligned. Landmark matching surface registration can then be obtained from the landmark aligned parameterizations. For genus-0 closed brain surfaces, the optimized spherical harmonic parameterization, which aligns landmarks to consistent locations on the sphere, has been widely used. This approach is limited by the loss of bijectivity under large deformations and the slow computation. In this paper, we propose FLASH, a fast algorithm to compute the optimized spherical harmonic parameterization with consistent landmark alignment. This is achieved by formulating the optimization problem to ℂ and thereby linearizing the problem. Errors introduced near the pole are corrected using quasiconformal theories. Also, by adjusting the Beltrami differential of the mapping, a diffeomorphic (1-1, onto) spherical parameterization can be effectively obtained. The proposed algorithm has been tested on 38 human brain surfaces. Experimental results demonstrate that the computation of the landmark aligned spherical harmonic parameterization is significantly accelerated using the proposed algorithm.

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We introduce a new equivalence relation for complete alge- braic varieties with canonical singularities, generated by birational equivalence, by flat algebraic deformations (of varieties with canon- ical singularities), and by quasi-´etale morphisms, i.e., morphisms which are unramified in codimension 1. We denote the above equivalence by A.Q.E.D. : = Algebraic-Quasi-´ Etale- Deformation. A completely similar equivalence relation, denoted by C-Q.E.D., can be considered for compact complex spaces with canonical sin- gularities. By a recent theorem of Siu, dimension and Kodaira dimension are invariants for A.Q.E.D. of complex varieties. We address the interesting question whether conversely two al- gebraic varieties of the same dimension and with the same Ko- daira dimension are Q.E.D. - equivalent (A.Q.E.D., or at least C-Q.E.D.), the answer being positive for curves by well known results. Using Enriques’ (resp. Kodaira’s) classification we show first that the answer to the C-Q.E.D. question is positive for special algebraic surfaces (those with Kodaira dimension at most 1), resp. for compact complex surfaces with Kodaira dimension 0, 1 and even first Betti number. The appendix by S¨onke Rollenske shows that the hypothesis of even first Betti number is necessary: he proves that any sur- face which is C-Q.E.D.-equivalent to a Kodaira surface is itself a Kodaira surface. We show also that the answer to the A.Q.E.D. question is pos- itive for complex algebraic surfaces of Kodaira dimension ≤ 1. The answer to the Q.E.D. question is instead negative for sur- faces of general type: the other appendix, due to Fritz Grunewald, is devoted to showing that the (rigid) Kuga-Shavel type surfaces of general type obtained as quotients of the bidisk via discrete groups constructed from quaternion algebras belong to countably many distinct Q.E.D. equivalence classes.

We show that given $${n \geqslant 3}$$ , $${q \geqslant 1}$$ , and a finite set $${\{y_1, \ldots, y_q \}}$$ in $${\mathbb{R}^n}$$ there exists a quasiregular mapping $${\mathbb{R}^n\to \mathbb{R}^n}$$ omitting exactly points $${y_1, \ldots, y_q}$$ .