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Over time, a population acquires neutral genetic substitutions as a consequence of random drift. A famous result in population genetics asserts that the rate, K, at which these substitutions accumulate in the population coincides with the mutation rate, u, at which they arise in individuals: K = u. This identity enables genetic sequence data to be used as a “molecular clock” to estimate the timing of evolutionary events. While the molecular clock is known to be perturbed by selection, it is thought that K = u holds very generally for neutral evolution. Here we show that asymmetric spatial population structure can alter the molecular clock rate for neutral mutations, leading to either K<u or K>u. Our results apply to a general class of haploid, asexually reproducing, spatially structured populations. Deviations from K = u occur because mutations arise unequally at different sites and have different probabilities of fixation depending on where they arise. If birth rates are uniform across sites, then K
u. In general, K can take any value between 0 and Nu. Our model can be applied to a variety of population structures. In one example, we investigate the accumulation of genetic mutations in the small intestine. In another application, we analyze over 900 Twitter networks to study the effect of network topology on the fixation of neutral innovations in social evolution.

The notion of central stability was first formulated for sequences of representations of the symmetric groups by Putman. A categorical reformulation was subsequently given by Church, Ellenberg, Farb, and Nagpal using the notion of FI-modules, where FI is the category of finite sets and injective maps. We extend the notion of central stability from FI to a wide class of categories, and prove that a module is presented in finite degrees if and only if it is centrally stable. We also introduce the notion of d-step central stability, and prove that if the ideal of relations of a category is generated in degrees at most d, then every module presented in finite degrees is d-step centrally stable.

In [2], J. Arthur classifies the automorphic discrete spectrum of symplectic groups up to global Arthur packets. We continue with our investigation of Fourier coefficients and their implication to the structure of the cuspidal spectrum for symplectic groups ([16] and [20]). As result, we obtain certain characterization and construction of small cuspidal automorphic representations and gain a better understanding of global Arthur packets and of the structure of local unramified components of the cuspidal spectrum, which has impacts to the generalized Ramanujan problem as posted by P. Sarnak in [43].

This article is a continuation of our work on the classification of holomorphic framed vertex operator algebras of central charge 24. We show that a holomorphic framed VOA of central charge 24 is uniquely determined by the Lie algebra structure of its weight one subspace. As a consequence, we completely classify all holomorphic framed vertex operator algebras of central charge 24 and show that there exist exactly 56 such vertex operator algebras, up to isomorphism.