Alzheimer's disease (AD) is a no-cure disease that has been frustrating the scientists for many years. Analyzing the disease has become an important but challenging research topic. The shape analysis of the sub-cortical structure of AD patients has been commonly used to understand this disease. In this paper, we assess the feasibility of using shape information on the hippocampal (HP) surfaces to detect some sub-structural changes in AD patients. We propose a quasi-conformal statistical shape analysis model, which allows us to study local regional geometric changes in the HPs amongst normal control (NC) and AD groups. A shape index defined by the quasi-conformality and surface curvatures is used to characterize region-specific shape variations of the HP surfaces. Feature vectors can be extracted for each HPs, with which a classification model can be built using machine learning methods to classify HPs into NC and AD subjects. Experiments have been carried out on 99 normal controls and 41 patients with AD. Results demonstrate that the proposed quasi-conformal based model is effective for classifying HPs into NC and AD groups with high classification accuracy (with highest overall classification accuracy reaching 87.86% in a leave-one-out experiment using the whole dataset).

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This paper studies affine Deligne-Lusztig varieties $X_{w}(b)$ in the affine flag variety of a quasi-split tamely ramified group. We describe the geometric structure of $X_{w}(b)$ for a minimal length element $w$ in the conjugacy class of an extended affine Weyl group, generalizing one of the main results in \cite{HL} to the affine case. We then provide a reduction method that relates the structure of $X_{w}(b)$ for arbitrary elements $w$ in the extended affine Weyl group to those associated with minimal length elements. Based on this reduction, we establish a connection between the dimension of affine Deligne-Lusztig varieties and the degree of the class polynomial of affine Hecke algebras. As a consequence, we prove a conjecture of G\"ortz, Haines, Kottwitz and Reuman in \cite{GHKR}.

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In [2], J. Arthur classifies the automorphic discrete spectrum of symplectic groups up to global Arthur packets. We continue with our investigation of Fourier coefficients and their implication to the structure of the cuspidal spectrum for symplectic groups ([16] and [20]). As result, we obtain certain characterization and construction of small cuspidal automorphic representations and gain a better understanding of global Arthur packets and of the structure of local unramified components of the cuspidal spectrum, which has impacts to the generalized Ramanujan problem as posted by P. Sarnak in [43].