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We prove the BMV (Bessis, Moussa, Villani, [1]) conjecture, which states that the function $${t \mapsto \mathop{\rm Tr}\exp(A-tB)}$$ , $${t \geqslant 0}$$ , is the Laplace transform of a positive measure on [0,∞) if$A$and$B$are $${n \times n}$$ Hermitian matrices and$B$is positive semidefinite. A semi-explicit representation for this measure is given.

Adult stem cells, which exist throughout the body, multiply by cell division to replenish dying cells or to promote regeneration to repair damaged tissues. To perform these functions during the lifetime of organs or tissues, stem cells need to maintain their populations in a faithful distribution of their epigenetic states, which are suscepti- ble to stochastic fluctuations during each cell division, unexpected injury, and potential genetic mutations that occur during many cell divisions. However, it remains unclear how the three processes of differentiation, proliferation, and apoptosis in regulating stem cells collectively manage these challenging tasks. Here, without consid- ering molecular details, we propose a genetic optimal control model for adult stem cell regeneration that includes the three fundamental processes, along with cell division and adaptation based on differ- ential fitnesses of phenotypes. In the model, stem cells with a distri- bution of epigenetic states are required to maximize expected performance after each cell division. We show that heteroge- neous proliferation that depends on the epigenetic states of stem cells can improve the maintenance of stem cell distributions to create balanced populations. A control strategy during each cell division leads to a feedback mechanism involving heterogeneous proliferation that can accelerate regeneration with less fluctuation in the stem cell population. When mutation is allowed, apoptosis evolves to maximize the performance during homeostasis after multiple cell divisions. The overall results highlight the importance of cross-talk between genetic and epigenetic regulation and the performance objectives during homeostasis in shaping a desirable heterogeneous distribution of stem cells in epigenetic states.

In this paper, we study the transonic shock problem for the full compressible Euler system in a general two-dimensional de Laval nozzle as proposed in Courant and Friedrichs (Supersonic flow and shock waves, Interscience, New York, 1948): given the appropriately large exit pressure pe(x), if the upstream flow is still supersonic behind the throat of the nozzle, then at a certain place in the diverging part of the nozzle, a shock front intervenes and the gas is compressed and slowed down to subsonic speed so that the position and the strength of the shock front are automatically adjusted such that the end pressure at the exit becomes pe(x). We solve this problem completely for a general class of de Laval nozzles whose divergent parts are small and arbitrary perturbations of divergent angular domains for the full steady compressible Euler system. The problem can be reduced to solve a nonlinear free boundary value problem for a mixed hyperbolic–elliptic system. One of the key ingredients in the analysis is to solve a nonlinear free boundary value problem in a weighted Hölder space with low regularities for a second order quasilinear elliptic equation with a free parameter (the position of the shock curve at one wall of the nozzle) and non-local terms involving the trace on the shock of the first order derivatives of the unknown function.

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