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Given a Lagrangian sphere in a symplectic 4–manifold $(M, \omega)$ with $b^{+}=1$, we find embedded symplectic surfaces intersecting it minimally. When the Kodaira dimension  $\kappa$ of $(M,\omega)$ is $-\infty$, this minimal intersection property turns out to be very powerful for both the uniqueness and existence problems of Lagrangian spheres. On the uniqueness side, for a symplectic rational manifold and any class which is not characteristic, we show that homologous Lagrangian spheres are smoothly isotopic, and when the Euler number is less than 8, we generalize Hind and Evans’ Hamiltonian uniqueness in the monotone case. On the existence side, when  $\kappa=-\infty$, we give a characterization of classes represented by Lagrangian spheres, which enables us to describe the non-Torelli part of the symplectic mapping class group.

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Recent work explores the candidate phases of the 4d adjoint quantum chromodynamics (QCD$_4$) with an SU(2) gauge group and two massless adjoint Weyl fermions. Both Cordova-Dumitrescu and Bi-Senthil propose possible low energy 4d topological quantum field theories (TQFTs) to saturate the higher 't Hooft anomalies of adjoint QCD$_4$ under a renormalization-group (RG) flow from high energy. In this work, we generalize the symmetry-extension method [arXiv:1705.06728] to higher symmetries, and formulate higher group cohomology and cobordism theory approach to construct higher-symmetric TQFTs. We prove that the symmetry-extension method saturates certain anomalies, but also prove that neither $A \mathcal{P}_2(B_2)$ nor $\mathcal{P}_2(B_2)$ can be fully trivialized, with the background 1-form field $A$, Pontryagin square $\mathcal{P}_2$ and 2-form field $B_2$. Surprisingly, this indicates an obstruction to constructing a fully 1-form center and 0-form chiral symmetry (full discrete axial symmetry) preserving 4d TQFT with confinement, a no-go scenario via symmetry-extension for specific higher anomalies. We comment on the implications and constraints on deconfined quantum critical points (dQCP), quantum spin liquids (QSL) or quantum fermionic liquids in condensed matter, and ultraviolet-infrared (UV-IR) duality in 3+1 spacetime dimensions.

We propose a computational framework named iterative local adaptive majorize-minimization (I-LAMM) to simultaneously control algorithmic complexity and statistical error when fitting high dimensional models. I-LAMM is a two-stage algorithmic implementation of the local linear approximation to a family of folded concave penalized quasi-likelihood. The first stage solves a convex program with a crude precision tolerance to obtain a coarse initial estimator, which is further refined in the second stage by iteratively solving a sequence of convex programs with smaller precision tolerances. Theoretically, we establish a phase transition: the first stage has a sublinear iteration complexity, while the second stage achieves an improved linear rate of convergence. Though this framework is completely algorithmic, it provides solutions with optimal statistical performances and controlled algorithmic complexity for a large family