We consider the flow of closed convex hypersurfaces in Euclidean space R^{n+1} with speed given by a power of the k-th mean curvature E_k plus a global term chosen to impose a constraint involving the enclosed volume V_{n+1} and the mixed volume V_{n+1−k} of the evolving hypersurface. We prove that if the initial hypersurface is strictly convex, then the solution of the flow exists for all time and converges to a round sphere smoothly. No curvature pinching assumption is required on the initial hypersurface.

In this paper, we introduce multiscale persistent functions for biomolecular structure characterization. The essential idea is to combine our multiscale rigidity functions with persistent homology analysis, so as to construct a series of multiscale persistent functions, particularly multiscale persistent entropies, for structure characterization. To clarify the fundamental idea of our method, the multiscale persistent entropy model is discussed in great detail. Mathematically, unlike the previous persistent entropy or topological entropy, a special resolution parameter is incorporated into our model. Various scales can be achieved by tuning its value. Physically, our multiscale persistent entropy can be used in conformation entropy evaluation. More specifically, it is found that our method incorporates in it a natural classification scheme. This is achieved through a density filtration of a multiscale rigidity function built from bond and/or dihedral angle distributions. To further validate our model, a systematical comparison with the traditional entropy evaluation model is done. It is found that our model is able to preserve the intrinsic topological features of biomolecular data much better than traditional approaches, particularly for resolutions in the mediate range. Moreover, our method can be successfully used in protein classification. For a test database with around nine hundred proteins, a clear separation between all-alpha and all-beta proteins can be achieved, using only the dihedral and pseudo-bond angle information. Finally, a special protein structure index (PSI) is proposed, for the first time, to describe the "regularity" of protein structures. Essentially, PSI can be used to describe the "regularity" information in any systems.

We consider the numerical solution of the time-fractional diffusion-wave equation on two-dimensional and three-dimensional unbounded spatial domains. Introduce an artificial boundary and find the exact and approximate artificial boundary conditions for the given problem, which lead to a bounded computational domain. Using the exact or approximating boundary conditions on the artificial boundary, the original problem is reduced to an initial-boundary-value problem on the bounded computational domain which is respectively equivalent to or approximates the original problem. Finite difference methods are used to solve the reduced problems on the bounded computational domain and the stability of these finite difference methods are proved. The numerical results demonstrate that the method given in this paper is effective and feasible.

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