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In this paper we establish new $L^1$-type estimates for the classical Riesz potentials of order $\alpha \in (0, N)$: \[ \|I_\alpha u\|_{L^{N/(N-\alpha)}(\mathbb{R}^N)} \leq C \|Ru\|_{L^1(\mathbb{R}^N;\mathbb{R}^N)}. \] This sharpens the result of Stein and Weiss on the mapping properties of Riesz potentials on the real Hardy space $\mathcal{H}^1(\mathbb{R}^N)$ and provides a new family of $L^1$-Sobolev inequalities for the Riesz fractional gradient.

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Next-generation sequencing technology enables the routine detection of bacterial pathogens for clinical diagnostics and genetic research. Whole-genome sequencing has been of importance in the epidemiologic analysis of bacterial pathogens. However, few whole-genome sequencing-based genotyping pipelines are available for practical applications. Here, we present the whole-genome sequencing-based single nucleotide polymorphism(SNP) genotyping method and apply to the evolutionary analysis of methicillin-resistant Staphylococcus aureus. The SNP genotyping method calls genome variants using next-generation sequencing reads of whole genomes and calculates the pair-wise Jaccard distances of the genome variants. The method may reveal the high-resolution whole-genome SNP profiles and the structural variants of different isolates of methicillin-resistant S. aureus(MRSA) and methicillin-susceptible S. aureus(MSSA) strains. The phylogenetic analysis of whole genomes and particular regions may monitor and track the evolution and the transmission dynamic of bacterial pathogens. The computer pro- grams of the whole genome sequencing-based SNP genotyping methods are available to the public at https://github. com/ cyinbox/NGS.