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Genome comparison is a vital research area of bioinformatics. For large-scale genome comparisons, the Multiple Sequence Alignment (MSA) methods have been impractical to use due to its algorithmic complexity. In this study, we propose a novel alignment-free method based on the one-to-one correspondence between a DNA sequence and its complete central moment vector of the cumulative Fourier power and phase spectra. In addition, the covariance between the four nucleotides in the power and phase spectra is included. We use the cumulative Fourier power and phase spectra to define a 28-dimensional vector for each DNA sequence. Euclidean distances between the vectors can measure the dissimilarity between DNA sequences. We perform testing with datasets of different sizes and types including simulated DNA sequences, exon-intron and complete genomes. The results show that our method is more accurate and efficient for performing hierarchical clustering than other alignment-free methods and MSA methods.

Inthisarticle,weprovideasufficientandnecessaryconditiononparabolic isometries of positive translation lengths on complete visibility CAT(0) spaces. One of the consequences is that each parabolic isometry of a complete simply connected visibility manifold of nonpositive sectional curvature has zero translation length. Applications on the geometry of open negatively curved manifolds will also be discussed.

The universal Teichmu¨ller space is an infinitely dimensional generalization of the classical Teichmu¨ller space of Riemann surfaces. It carries a natural Hilbert structure, on which one can define a natural Riemannian metric, the Weil-Petersson metric. In this paper we investigate the Weil-Petersson Riemannian curvature operator ˜ Q of the universal Teichmu¨ller space with the Hilbert structure, and prove the following: (i) ˜ Q is non-positive definite. (ii) ˜ Q is a bounded operator. (iii) ˜ Q is not compact; the set of the spectra of ˜ Q is not discrete. As an application, we show that neither the Quaternionic hyperbolic space nor the Cayley plane can be totally geodesically immersed in the universal Teichmu¨ller space endowed with the Weil-Petersson metric.

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