Recent work explores the candidate phases of the 4d adjoint quantum chromodynamics (QCD$_4$) with an SU(2) gauge group and two massless adjoint Weyl fermions. Both Cordova-Dumitrescu and Bi-Senthil propose possible low energy 4d topological quantum field theories (TQFTs) to saturate the higher 't Hooft anomalies of adjoint QCD$_4$ under a renormalization-group (RG) flow from high energy. In this work, we generalize the symmetry-extension method [arXiv:1705.06728] to higher symmetries, and formulate higher group cohomology and cobordism theory approach to construct higher-symmetric TQFTs. We prove that the symmetry-extension method saturates certain anomalies, but also prove that neither $A \mathcal{P}_2(B_2)$ nor $\mathcal{P}_2(B_2)$ can be fully trivialized, with the background 1-form field $A$, Pontryagin square $\mathcal{P}_2$ and 2-form field $B_2$. Surprisingly, this indicates an obstruction to constructing a fully 1-form center and 0-form chiral symmetry (full discrete axial symmetry) preserving 4d TQFT with confinement, a no-go scenario via symmetry-extension for specific higher anomalies. We comment on the implications and constraints on deconfined quantum critical points (dQCP), quantum spin liquids (QSL) or quantum fermionic liquids in condensed matter, and ultraviolet-infrared (UV-IR) duality in 3+1 spacetime dimensions.

We explore various 4d Yang-Mills gauge theories (YM) living as boundary conditions of 5d gapped short/long-range entangled (SRE/LRE) topological states. Specifically, we explore 4d time-reversal symmetric pure YM of an SU(2) gauge group with a second-Chern-class topological term at θ=π (SU(2)θ=π YM). Its higher 't Hooft anomalies of generalized global symmetries indicate that the 4d SU(2)θ=π YM, in order to realize all global symmetries locally, necessarily couples to a 5d higher symmetry-protected topological state (SPTs, as an invertible TQFT, or as a 5d 1-form-center-symmetry-protected interacting "topological superconductor" in condensed matter). We revisit the 4d SU(2)θ=π YM-5d SRE-higher-SPTs coupled systems in [arXiv:1812.11968] and find their "Fantastic Four Siblings" with four sets of new higher anomalies associated with the Kramers singlet/doublet and bosonic/fermionic properties of Wilson lines. Following Weyl's gauge principle, by dynamically gauging the 1-form center symmetry, we transform a 5d bulk SRE SPTs into an LRE symmetry-enriched topologically ordered state (SETs); thus we obtain the 4d SO(3)θ=π YM-5d LRE-higher-SETs coupled system with dynamical higher-form gauge fields. Apply the tool introduced in [arXiv:1612.09298], we derive new exotic anyonic statistics of extended objects such as 2-worldsheet of strings and 3-worldvolume of branes, which physically characterize the 5d SETs. We discover new triple and quadruple link invariants potentially associated with the underlying 5d higher-gauge TQFTs, hinting a new intrinsic relation between non-supersymmetric 4d pure YM and topological links in 5d. We provide lattice simplicial complex regularizations and "condensed matter" realizations.

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