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In this paper, we will derive some twist criteria for the periodic solution of a periodic scalar Newtonian equation using the third order approximation. As an application to the forced pendulum x ̈ + ω^2 sin x = p(t), we will find an explicit bound P (ω) for the L1 norm, ∥p∥1, of the periodicforcingp(t)usingthefrequencyωasaparametersuchthattheleastamplitudeperiodic solution of the forced pendulum is of twist type when ∥p∥1 < P (ω). The bound P (ω) has the order of O(ω1/2) when ω is bounded away from resonance of orders ≤ 4 and ω → +∞.

Differential Galois theory has played important roles in the the- ory of integrability of linear differential equation. In this paper we will extend the theory to nonlinear case and study the integrability of the first order non- linear differential equation. We will define for the differential equation the differential Galois group, will study the structure of the group, and will prove the equivalent between the existence of the Liouvillian first integral and the solvability of the corresponding differential Galois group.

This paper studies the moment boundedness of solutions of linear stochastic delay differential equations with distributed delay. For a linear stochastic delay differential equation, the rst moment stability is known to be identical to that of the corresponding deterministic delay differential equation. However, boundedness of the second moment is complicated and depends on the stochastic terms. In this paper, the characteristic function of the equation is obtained through techniques of the Laplace transform. From the characteristic equation, suf cient conditions for the second moment to be bounded or unbounded are proposed.

Adult stem cells, which exist throughout the body, multiply by cell division to replenish dying cells or to promote regeneration to repair damaged tissues. To perform these functions during the lifetime of organs or tissues, stem cells need to maintain their populations in a faithful distribution of their epigenetic states, which are suscepti- ble to stochastic fluctuations during each cell division, unexpected injury, and potential genetic mutations that occur during many cell divisions. However, it remains unclear how the three processes of differentiation, proliferation, and apoptosis in regulating stem cells collectively manage these challenging tasks. Here, without consid- ering molecular details, we propose a genetic optimal control model for adult stem cell regeneration that includes the three fundamental processes, along with cell division and adaptation based on differ- ential fitnesses of phenotypes. In the model, stem cells with a distri- bution of epigenetic states are required to maximize expected performance after each cell division. We show that heteroge- neous proliferation that depends on the epigenetic states of stem cells can improve the maintenance of stem cell distributions to create balanced populations. A control strategy during each cell division leads to a feedback mechanism involving heterogeneous proliferation that can accelerate regeneration with less fluctuation in the stem cell population. When mutation is allowed, apoptosis evolves to maximize the performance during homeostasis after multiple cell divisions. The overall results highlight the importance of cross-talk between genetic and epigenetic regulation and the performance objectives during homeostasis in shaping a desirable heterogeneous distribution of stem cells in epigenetic states.