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This book presents an overview of recent developments in biostatistics and bioinformatics. Written by active researchers in these emerging areas, it is intended to give graduate students and new researchers an idea of where the frontiers of biostatistics and bioinformatics are as well as a forum to learn common techniques in use, so that they can advance the fields via developing new techniques and new results. Extensive references are provided so that researchers can follow the threads to learn more comprehensively what the literature is and to conduct their own research. In particulars, the book covers three important and rapidly advancing topics in biostatistics: analysis of survival and longitudinal data, statistical methods for epidemiology, and bioinformatics.

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A BDDC (Balancing Domain Decomposition by Constraints) algorithm is developed and analyzed for a staggered discontinuous Galerkin (DG) finite element approximation of second order scalar elliptic problems. On a quite irregular subdomain partition, an optimal condition number bound is proved for two-dimensional problems. In addition, a sub-optimal but scalable condition number bound is obtained for three-dimensional problems. These bounds are shown to be independent of coefficient jumps in the subdomain partition. Numerical results are also included to show the performance of the algorithm.

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We study the relationship between TsT transformations, marginal deformations of string theory on AdS3 backgrounds, and irrelevant deformations of 2d CFTs. We show that TsT transformations of NS-NS backgrounds correspond to instantaneous deformations of the worldsheet action by the antisymmetric product of two Noether currents, holographically mirroring the definition of the TT¯, JT¯, TJ¯, and JJ¯ deformations of 2d CFTs. Applying a TsT transformation to string theory on BTZ ×S^3×M^4 we obtain a general class of rotating black string solutions, including the Horne-Horowitz and the Giveon-Itzhaki-Kutasov ones as special cases, which we show are holographically dual to thermal states in single-trace TT¯-deformed CFTs. We also find a smooth solution interpolating between global AdS3 in the IR and a linear dilaton background in the UV that is interpreted as the NS-NS ground state in the dual TT¯-deformed CFT. This background suggests the existence of an upper bound on the deformation parameter above which the solution becomes complex. We find that the worldsheet spectrum, the thermodynamics of the black strings (in particular their Bekenstein-Hawking entropy), and the critical value of the deformation parameter match the corresponding quantities obtained from single-trace TT¯ deformations.

We propose a model for scattering in a flat resonator with a thin antenna. The results are applied to rectangular microwave cavities. We compute the resonance spacing distribution and show that it agrees well with experimental data provided the antenna radius is much smaller than wavelengths of the resonance wavefunctions.

In addition to the conventional renormalized-coupling-constant picture, point interactions in two and three dimensions are shown to model within a suitable energy range scattering on localized potentials, both attractive and repulsive.

We generate a class of string backgrounds by a sequence of TsT transformations of the NS1-NS5 system that we argue are holographically dual to states in a single-trace TT¯+JT¯+TJ¯-deformed CFT2. The new string backgrounds include general rotating black hole solutions with two U(1) charges as well as a smooth solution without a horizon that is interpreted as the ground state. As evidence for the correspondence we (i) derive the long string spectrum and relate it to the spectrum of the dual field theory; (ii) show that the black hole thermodynamics can be reproduced from single-trace TT¯+JT¯+TJ¯-deformed CFTs; and (iii) show that the energy of the ground state matches the energy of the vacuum in the dual theory. We also study geometric properties of these new spacetimes and find that for some choices of the parameters the three-dimensional Ricci scalar in the Einstein frame can become positive in a region outside the horizon before reaching closed timelike curves and singularities.

In this paper, we consider the numerical approximation of the three-dimensional poroelastic wave equations in the spherical coordinate system. One difficulty in the design of an efficient numerical scheme is that the problem is singular in the center and the polar axes of the computational domain. Nevertheless, we develop a hybrid finite difference/control volume method for solving this problem. Our method is explicit and is second order accurate in both space and time. Numerical results are shown to confirm the convergence rate of our method and the effectiveness to simulate wave propagation in poroelastic media in the spherical coordinate system.

In this paper, a class of FETI-DP preconditioners is developed for a fast solution of the linear system arising from staggered discontinuous Galerkin discretization of the two-dimensional Stokes equations. The discretization has been recently developed and has the distinctive advantages that it is optimally convergent and has a good local conservation property. In order to efficiently solve the linear system, two kinds of FETI-DP preconditioners, namely, lumped and Dirichlet preconditioners, are considered and analyzed. Scalable bounds C (H/h) and C (1+ log (H/h)) 2 are proved for the lumped and Dirichlet preconditioners, respectively, with the constant C depending on the infsup constant of the discrete spaces but independent of any mesh parameters. Here H/h stands for the number of elements across each subdomain. Numerical results are presented to confirm the theoretical estimates.

In this paper, gold ball wire bonding at low temperature using a high frequency transducer was evaluated. The substrates used were FR-4 laminates with two different gold-plated surface finishes: electrolytic and immersion gold-plated. Bonding temperatures of 120/spl deg/C, 80/spl deg/C and 40/spl deg/C were investigated with 1 mil fine pitch gold wire. Prior to wire bonding, the laminates and dice were plasma treated. The surfaces were analyzed prior to and after plasma treatment before wire bonding using XPS and AFM. Bonded areas were also analyzed using SEM. Design of experiment (DOE) techniques have been employed to optimize the bonding parameters at each temperature. The response of the DOE was evaluated by using bond shear and bond pull. The results show that bonding at low temperature is viable with the use of a high frequency transducer wire bonder.

Open quantum walks (also known as open quantum random walks) are quantum analogs of classical Markov chains in probability theory, and have potential application in quan- tum information and quantum computation. Quantum Bernoulli noises are annihilation and creation operators acting on Bernoulli functionals, and can be used as the environ- ment of an open quantum system. In this paper, by using quantum Bernoulli noises as the environment, we introduce an open quantum walk on a general higher-dimensional integer lattice. We obtain a quantum channel representation of the walk, which shows that the walk is indeed an open quantum walk. We prove that all the states of the walk are separable provided its initial state is separable. We also prove that, for some initial states, the walk has a limit probability distribution of higher-dimensional Gauss type. Finally we show links between the walk and a unitary quantum walk recently introduced in terms of quantum Bernoulli noises.

Resolution Matrix Semantics (RMS) introduces a novel truth-value-based framework for modal logic, providing a substantive alternative to Kripke’s relational semantics of possible worlds. Drawing inspiration from Y. Ivlev’s substantive semantics, RMS utilizes a 4-valued structure—necessary truth (tn), contingent truth (tc), contingent false (fc), and necessary false (fn)—augmented by indeterminate values (t, f, t/f) to define modal systems Km, KDm, KTm, S4m, and S5m, analogous to Kripke’s K, KD, T, S4, and S5. By directly assigning determined and indeterminate truth values via an interpretation function, RMS validates formulas without relying on accessibility relations, as demonstrated through soundness and completeness proofs and a tailored tableau method. The framework’s versatility extends to applications in deontic logic, artificial intelligence, and quantum computing, enabling context-dependent reasoning with computational efficiency. RMS thus bridges philosophical logic and practical domains, offering a truth-centric perspective on modal reasoning’s complexities.

We observe that some self-similar measures defined by finite or infinite iterated function systems with overlaps satisfy certain "bounded measure type condition", which allows us to extract useful measure-theoretic properties of iterates of the measure. We develop a technique to obtain a closed formula for the spectral dimension of the Laplacian defined by self-similar measure satisfying this condition. For Laplacians defined by fractal measures with overlaps, spectral dimension has been obtained earlier only for a small class of one-dimensional self-similar measures satisfying Strichartz second-order self-similar identities. The main technique we use relies on the vector-valued renewal theorem proved by Lau, Wang and Chu.

In this paper, we will prove the Weyl's law for the asymptotic formula of Dirichlet eigenvalues on metric measure spaces with generalized Ricci curvature bounded from below.

We describe an inductive machinery to prove various properties of representations of a category equipped with a generic shift functor. Specifically, we show that if a property (P) of representations of the category behaves well under the generic shift functor, then all finitely generated representations of the category have the property (P). In this way, we obtain simple criteria for properties such as Noetherianity, finiteness of Castelnuovo-Mumford regularity, and polynomial growth of dimension to hold. This gives a systemetic and uniform proof of such properties for representations of the categories $\FI_G$ and $\OI_G$ which appear in representation stability theory.

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