Let G=(V,E) be a locally finite connected weighted graph, and Δ be the usual graph Laplacian. In this article, we study blow-up problems for the nonlinear parabolic equation u_t = Δu + f(u) on G. The blow-up phenomenons for u_t = Δu + f(u) are discussed in terms of two cases: (i) an initial condition is given; (ii) a Dirichlet boundary condition is given. We prove that if f satisfies appropriate conditions, then the corresponding solutions will blow up in a finite time.