The quantitative comparison of two or more microarrays can reveal, for example, the distinct patterns of gene expression that define different cellular phenotypes or the genes that are induced in the cellular response to certain stimulations. Normalization of the measured intensities is a prerequisite of such comparisons. However, a fundamental problem in cDNA microarray analysis is the lack of a common standard to compare the expression levels of different samples. Several normalization protocols have been proposed to overcome the variabilities inherent in this technology. We have developed a normalization procedure based on within-array replications via a semilinear in-slide model, which adjusts objectively experimental variations without making critical biological assumptions. The significant analysis of gene expressions is based on a weighted <i>t</i> statistic, which accounts for the heteroscedasticity of the

High throughput genetic sequencing arrays with thousands of measurements per sample and a great amount of related censored clinical data have increased demanding need for better measurement specific model selection. In this paper we establish strong oracle properties of non-concave penalized methods for non-polynomial (NP) dimensional data with censoring in the framework of Coxs proportional hazards model. A class of folded-concave penalties are employed and both LASSO and SCAD are discussed specifically. We unveil the question under which dimensionality and correlation restrictions can an oracle estimator be constructed and grasped. It is demonstrated that non-concave penalties lead to significant reduction of the irrepresentable condition needed for LASSO model selection consistency. The large deviation result for martingales, bearing interests of its own, is developed for characterizing

We discuss the difficulties of estimating quadratic functionals based on observations Y (t) from the white noise model Y (t) where Y (t) is a standard Wiener process on Y (t) . The optimal rates of convergence (as Y (t) ) for estimating quadratic functionals under certain geometric constraints are found. Specifically, the optimal rates of estimating Y (t) under hyperrectangular constraints Y (t) and weighted Y (t) -body constraints Y (t) are computed explicitly, where Y (t) is the Y (t) th Fourier-Bessel coefficient of the unknown function Y (t) . We develop lower bounds based on testing two highly composite hypercubes and address their advantages. The attainable lower bounds are found by applying the hardest one-dimensional approach as well as the hypercube method. We demonstrate that for estimating regular quadratic functionals [ie, the functionals which can be estimated

This paper considers a proportional hazards model, which allows one to examine the extent to which covariates interact nonlinearly with an exposure variable, for analysis of lifetime data. A local partial-likelihood technique is proposed to estimate nonlinear interactions. Asymptotic normality of the proposed estimator is established. The baseline hazard function, the bias and the variance of the local likelihood estimator are consistently estimated. In addition, a one-step local partial-likelihood estimator is presented to facilitate the computation of the proposed procedure and is demonstrated to be as efficient as the fully iterated local partial-likelihood estimator. Furthermore, a penalized local likelihood estimator is proposed to select important risk variables in the model. Numerical examples are used to illustrate the effectiveness of the proposed procedures.

Portfolio allocation with gross-exposure constraint is an effective method to increase the efficiency and stability of portfolios selection among a vast pool of assets, as demonstrated by Fan, Zhang, and Yu. The required high-dimensional volatility matrix can be estimated by using high-frequency financial data. This enables us to better adapt to the local volatilities and local correlations among a vast number of assets and to increase significantly the sample size for estimating the volatility matrix. This article studies the volatility matrix estimation using high-dimensional, high-frequency data from the perspective of portfolio selection. Specifically, we propose the use of pairwise-refresh time and all-refresh time methods based on the concept of refresh time proposed by Barndorff-Nielsen, Hansen, Lunde, and Shephard for the estimation of vast covariance matrix and compare their merits in the portfolio selection. We