In an event-related functional MRI data analysis, an accurate and robust extraction of the hemodynamic response function (HRF) and its associated statistics (e.g., magnitude, width, and time to peak) is critical to infer quantitative information about the relative timing of the neuronal events in different brain regions. The aim of this paper is to develop a multiscale adaptive smoothing model (MASM) to accurately estimate HRFs pertaining to each stimulus sequence across all voxels. MASM explicitly accounts for both spatial and temporal smoothness information, while incorporating such information to adaptively estimate HRFs in the frequency domain. One simulation study and a real data set are used to demonstrate the methodology and examine its finite sample performance in HRF estimation, which confirms that MASM significantly outperforms the existing methods including the smooth finite impulse

In the paper, we study the three-dimensional Prandtl equations, and prove that if one component of the tangential velocity field satisfies the monotonicity assumption in the normal direction, then the system is locally well-posed in the Gevrey function space with Gevrey index in ] 1, 2]. The proof relies on some new cancellation mechanism in the system in addition to those observed in the two-dimensional setting.

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Let (M, ω) be a compact symplectic 4-manifold with a compatible almost complex structure J. The problem of finding a J-compatible symplectic form with prescribed volume form is an almost-K¨ahler analogue of Yau’s theorem and is connected to a programme in symplectic topology proposed by Donaldson. We call the corresponding equation for the symplectic form the Calabi- Yau equation. Solutions are unique in their cohomology class. It is shown in this paper that a solution to this equation exists if the Nijenhuis tensor is small in a certain sense. Without this assumption, it is shown that the problem of existence can be reduced to obtaining a C0 bound on a scalar potential function.

We study the mean curvature evolution of smooth, closed, twoconvex hypersurfaces in Rn+1 for n ≥ 3.Within this framework we effect a reconciliation between the flow with surgeries—recently constructed by Huisken and Sinestrari in [HS3]—and the wellknown weak solution of the level-set flow: we prove that the two solutions agree in an appropriate limit of the surgery parameters and in a precise quantitative sense. Our proof relies on geometric estimates for certain Lp-norms of the mean curvature which are of independent interest even in the setting of classicalmean curvature flow. We additionally show how our construction can be used to pass these estimates to limits and produce regularity results for the weak solution.