There is an unmet medical need to identify neuroimaging biomarkers that is able to accurately diagnose and monitor Alzheimer's disease (AD) at very early stages and assess the response to AD-modifying therapies. To a certain extent, volumetric and functional magnetic resonance imaging (fMRI) studies can detect changes in structure, cerebral blood flow and blood oxygenation that are able to distinguish AD and mild cognitive impairment (MCI) subjects from normal controls. However, it has been challenging to use fully automated MRI analytic methods to identify potential AD neuroimaging biomarkers. We have thus proposed a method based on independent component analysis (ICA), for studying potential AD-related MR image features, coupled with the use of support vector machine (SVM) for classifying scans into categories of AD, MCI, and normal control (NC) subjects. The MRI data were selected from Open Access Series of Imaging Studies (OASIS) and the Alzheimer's Disease Neuroimaging Initiative (ADNI) databases. The experimental results showed that our ICA-based method can differentiate AD and MCI subjects from normal controls, although further methodological improvement in the analytic method and inclusion of additional variables may be required for optimal classification.

Surface registration between cortical surfaces is crucial in medical imaging for performing systematic comparisons between brains. Landmark-matching registration that matches anatomical features, called the sulcal landmarks, is often required to obtain a meaningful 1-1 correspondence between brain surfaces. This is commonly done by parameterizing the surface onto a simple parameter domain, such as the unit sphere, in which the sulcal landmarks are consistently aligned. Landmark matching surface registration can then be obtained from the landmark aligned parameterizations. For genus-0 closed brain surfaces, the optimized spherical harmonic parameterization, which aligns landmarks to consistent locations on the sphere, has been widely used. This approach is limited by the loss of bijectivity under large deformations and the slow computation. In this paper, we propose FLASH, a fast algorithm to compute the optimized spherical harmonic parameterization with consistent landmark alignment. This is achieved by formulating the optimization problem to ℂ and thereby linearizing the problem. Errors introduced near the pole are corrected using quasiconformal theories. Also, by adjusting the Beltrami differential of the mapping, a diffeomorphic (1-1, onto) spherical parameterization can be effectively obtained. The proposed algorithm has been tested on 38 human brain surfaces. Experimental results demonstrate that the computation of the landmark aligned spherical harmonic parameterization is significantly accelerated using the proposed algorithm.

Let $K/k$ be a finite Galois extension and $\pi = \fn{Gal}(K/k)$. An algebraic torus $T$ defined over $k$ is called a $\pi$-torus if $T\times_{\fn{Spec}(k)} \fn{Spec}(K)\simeq \bm{G}_{m,K}^n$ for some integer $n$. The set of all algebraic $\pi$-tori defined over $k$ under the stably birational equivalence forms a semigroup, denoted by $T(\pi)$. We will give a complete proof of the following theorem due to Endo and Miyata \cite{EM4}. Theorem. Let $\pi$ be a finite group. Then $T(\pi)\simeq C(\Omega_{\bm{Z}\pi})$ where $\Omega_{\bm{Z}\pi}$ is a maximal $\bm{Z}$-order in $\bm{Q}\pi$ containing $\bm{Z}\pi$ and $C(\Omega_{\bm{Z}\pi})$ is the locally free class group of $\Omega_{\bm{Z}\pi}$, provided that $\pi$ is isomorphic to one of the following four types of groups : $C_n$ ($n$ is any positive integer), $D_m$ ($m$ is any odd integer $\ge 3$), $C_{q^f}\times D_m$ ($m$ is any odd integer $\ge 3$, $q$ is an odd prime number not dividing $m$, $f\ge 1$, and $(\bm{Z}/q^f\bm{Z})^{\times}=\langle \bar{p}\rangle$ for any prime divisor $p$ of $m$), $Q_{4m}$ ($m$ is any odd integer $\ge 3$, $p\equiv 3 \pmod{4}$ for any prime divisor $p$ of $m$).

Surface conformal maps between genus-0 surfaces play important roles in applied mathematics and engineering, with applications in medical image analysis and computer graphics. Previous work (Gu and Yau in Commun Inf Syst 2(2):121–146, 2002) introduces a variational approach, where global conformal parameterization of genus-0 surfaces was addressed through minimizing the harmonic energy, with two weaknesses: its gradient descent iteration is slow, and its solutions contain undesired parameterization foldings when the underlying surface has long sharp features. In this paper, we propose an algorithm that significantly accelerates the harmonic energy minimization and a method that iteratively removes foldings by taking advantages of the weighted Laplace–Beltrami eigen-projection. Experimental results show that the proposed approaches compute genus-0 surface harmonic maps much faster than the existing algorithm in Gu and Yau (Commun Inf Syst 2(2):121–146, 2002) and the new results contain no foldings.

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