There is an unmet medical need to identify neuroimaging biomarkers that is able to accurately diagnose and monitor Alzheimer's disease (AD) at very early stages and assess the response to AD-modifying therapies. To a certain extent, volumetric and functional magnetic resonance imaging (fMRI) studies can detect changes in structure, cerebral blood flow and blood oxygenation that are able to distinguish AD and mild cognitive impairment (MCI) subjects from normal controls. However, it has been challenging to use fully automated MRI analytic methods to identify potential AD neuroimaging biomarkers. We have thus proposed a method based on independent component analysis (ICA), for studying potential AD-related MR image features, coupled with the use of support vector machine (SVM) for classifying scans into categories of AD, MCI, and normal control (NC) subjects. The MRI data were selected from Open Access Series of Imaging Studies (OASIS) and the Alzheimer's Disease Neuroimaging Initiative (ADNI) databases. The experimental results showed that our ICA-based method can differentiate AD and MCI subjects from normal controls, although further methodological improvement in the analytic method and inclusion of additional variables may be required for optimal classification.

Surface conformal maps between genus-0 surfaces play important roles in applied mathematics and engineering, with applications in medical image analysis and computer graphics. Previous work (Gu and Yau in Commun Inf Syst 2(2):121–146, 2002) introduces a variational approach, where global conformal parameterization of genus-0 surfaces was addressed through minimizing the harmonic energy, with two weaknesses: its gradient descent iteration is slow, and its solutions contain undesired parameterization foldings when the underlying surface has long sharp features. In this paper, we propose an algorithm that significantly accelerates the harmonic energy minimization and a method that iteratively removes foldings by taking advantages of the weighted Laplace–Beltrami eigen-projection. Experimental results show that the proposed approaches compute genus-0 surface harmonic maps much faster than the existing algorithm in Gu and Yau (Commun Inf Syst 2(2):121–146, 2002) and the new results contain no foldings.

In the research of computer vision and machine perception, 3D objects are usually represented by 2-manifold triangular meshes M. In this paper, we present practical and efficient algorithms to construct iso-contours, bisectors, and Voronoi diagrams of point sites onM, based on an exact geodesic metric. Compared to euclidean metric spaces, the Voronoi diagrams onMexhibit many special properties that fail all of the existing euclidean Voronoi algorithms. To provide practical algorithms for constructing geodesicmetric- based Voronoi diagrams onM, this paper studies the analytic structure of iso-contours, bisectors, and Voronoi diagrams onM. After a necessary preprocessing of model M, practical algorithms are proposed for quickly obtaining full information about iso-contours, bisectors, and Voronoi diagrams on M. The complexity of the construction algorithms is also analyzed. Finally, three interesting applications—surface sampling and reconstruction, 3D skeleton extraction, and point pattern analysis—are presented that show the potential power of the proposed algorithms in pattern analysis.

We address the problem of detecting deformities on elastic surfaces. This is of great importance for shape analysis, with applications such as detecting abnormalities in biological shapes (e.g., brain structures). We propose an effective algorithm to detect abnormal deformations by generating quasi-conformal maps between the original and deformed surfaces. We firstly flatten the 3D surfaces conformally onto 2D rectangles using the discrete Yamabe flow and use them to compute a quasi-conformal map that matches internal features lying within the surfaces. The deformities on the elastic surface are formulated as non-conformal deformations, whereas normal deformations that preserve local geometry are formulated as conformal deformations. We then detect abnormalities by computing the Beltrami coefficient associated uniquely with the quasi-conformal map. The Beltrami coefficient is a complex-valued function defined on the surface. It describes the deviation of the deformation from conformality at each point. By considering the norm of the Beltrami coefficient, we can effectively segment the regions of abnormal changes, which are invariant under normal (non-rigid) deformations that preserve local geometry. Furthermore, by considering the argument of the Beltrami coefficient, we can capture abnormalities induced by local rotational changes. We tested the algorithm by detecting abnormalities on synthetic surfaces, 3D human face data and MRI-derived brain surfaces. Experimental results show that our algorithm can effectively detect abnormalities and capture local rotational alterations. Our method is also more effective than other existing methods, such as the isometric indicator, for locating abnormalities.

Registration, which aims to find an optimal 1-1 correspondence between shapes, is an important process in different research areas. Landmark-based surface registration has been widely studied to obtain a mapping between shapes that matches important features. Obtaining a unique and bijective surface registration that matches features consistently is generally challenging, especially when a large number of landmark constraints are enforced. This motivates us to search for a unique landmark matching surface diffeomorphism, which minimizes the local geometric distortion. For this purpose, we propose a special class of diffeomorphisms called the Teichmüller mappings (T-Maps). Under suitable conditions on the landmark constraints, a unique T-Map between two surfaces can be obtained, which minimizes the maximal conformality distortion. The conformality distortion measures how far the mapping deviates from a conformal mapping, and hence it measures the local geometric distortion. In this paper, we propose an efficient iterative algorithm, called the quasi-conformal (QC) iteration, to compute the T-Map. The basic idea is to represent the set of diffeomorphisms using Beltrami coefficients (BCs) and look for an optimal BC associated to the desired T-Map. The associated diffeomorphism can be efficiently reconstructed from the optimal BC using the linear Beltrami solver (LBS). Using BCs to represent diffeomorphisms guarantees the diffeomorphic property of the registration, even with very large deformation. Using our proposed method, the T-Map can be accurately and efficiently computed. The obtained registration is guaranteed to be bijective. The proposed algorithm can also be extended to compute T-Map with soft landmark constraints. We applied the proposed algorithm to real applications, such as brain landmark matching registration, constrained texture mapping, and human face registration. Experimental results shows that our method is both effective and efficient in computing a nonoverlap landmark matching registration with the least amount of conformality distortion.