There is an unmet medical need to identify neuroimaging biomarkers that allow us to accurately diagnose and monitor Alzheimer's disease (AD) at its very early stages and to assess the response to AD-modifying therapies. To a certain extent, volumetric and functional magnetic resonance imaging (fMRI) studies can detect changes in structure, cerebral blood flow, and blood oxygenation that distinguish AD and mild cognitive impairment (MCI) subjects from healthy control (HC) subjects. However, it has been challenging to use fully automated MRI analytic methods to identify potential AD neuroimaging biomarkers. We have thus proposed a method based on independent component analysis (ICA) for studying potential AD-related MR image features that can be coupled with the use of support vector machine (SVM) for classifying scans into categories of AD, MCI, and HC subjects. The MRI data were selected from

Fusion of images with same or different modalities has been conquering medical imaging field more rapidly due to the presence of highly accessible patients’ information in recent years. For example, cross platform non-rigid registration of CT with MRI images has found a significant role in different clinical application. In some instances labelling of anatomical features by medical experts are also involved to further improve the accuracy and authenticity of the registration. Being motivated by these, we propose a new algorithm to compute diffeomorphic hybrid multi-modality registration with large deformations. Our iterative scheme consists of mainly two steps. First, we obtain the optimal Beltrami coefficient corresponding to the diffeomorphic mapping that exactly superimposes the feature points. The second step detects the intensity difference in the framework of mutual information. A non-rigid deformation which minimizes the intensity difference is then obtained. Experiments have been carried out on both synthetic and real data. Results demonstrate the stability and efficacy of the proposed algorithm to obtain diffeomorphic image registration.

Here we propose a novel method to compute Teichmller shape space based shape index to study brain morphometry. Such a shape index is intrinsic, and invariant under conformal transformations, rigid motions and scaling. We conformally map a genus-zero open boundary surface to the Poincar disk with the Yamabe flow method. The shape indices that we compute are the lengths of a special set of geodesics under hyperbolic metric. Tests on longitudinal brain imaging data were used to demonstrate the stability of the derived feature vectors. In leave-one-out validation tests, we achieved 100% accurate classification (versus only 68% accuracy for volume measures) in distinguishing 11 HIV/AIDS individuals from 8 healthy control subjects, based on Teichmller coordinates for lateral ventricular surfaces extracted from their 3D MRI scans.

We propose a novel method to apply Teichmller space theory to study the signature of a family of nonintersecting closed 3D curves on a general genus zero closed surface. Our algorithm provides an efficient method to encode both global surface and local contour shape information. The signatureTeichmller shape descriptoris computed by surface Ricci flow method, which is equivalent to solving an elliptic partial differential equation on surfaces and is numerically stable. We propose to apply the new signature to analyze abnormalities in brain cortical morphometry. Experimental results with 3D MRI data from Alzheimers disease neuroimaging initiative (ADNI) dataset [152 healthy control subjects versus 169 Alzheimers disease (AD) patients] demonstrate the effectiveness of our method and illustrate its potential as a novel surface-based cortical morphometry measurement in AD research.

This paper presents a method to compute the quasi-conformal parameterization (QCMC) for a multiply-connected 2D domain or surface. QCMC computes a quasi-conformal map from a multiply-connected domain S onto a punctured disk D_S associated with a given Beltrami differential. The Beltrami differential, which measures the conformality distortion, is a complex-valued function μ: S→ℂ with supremum norm strictly less than 1. Every Beltrami differential gives a conformal structure of S. Hence, the conformal module of D_S, which are the radii and centers of the inner circles, can be fully determined by μ, up to a Möbius transformation. In this paper, we propose an iterative algorithm to simultaneously search for the conformal module and the optimal quasi-conformal parameterization. The key idea is to minimize the Beltrami energy subject to the boundary constraints. The optimal solution is our desired quasi-conformal parameterization onto a punctured disk. The parameterization of the multiply-connected domain simplifies numerical computations and has important applications in various fields, such as in computer graphics and vision. Experiments have been carried out on synthetic data together with real multiply-connected Riemann surfaces. Results show that our proposed method can efficiently compute quasi-conformal parameterizations of multiply-connected domains and outperforms other state-of-the-art algorithms. Applications of the proposed parameterization technique have also been explored.

In this paper, we introduce a novel method that can generate a sequence of physical transformations between 3D models with different shape and topology. Feasible transformations are realized on a chain structure with connected components that are 3D printed. Collision-free motions are computed to transform between different configurations of the 3D printed chain structure. To realize the transformation between different 3D models, we first voxelize these input models into similar number of voxels. The challenging part of our approach is to generate a simple path --- as a chain configuration to connect most voxels. A layer-based algorithm is developed with theoretical guarantee of the existence and the path length. We find that collision-free motion sequence can always be generated when using a straight line as the intermediate configuration of transformation. The effectiveness of our method is demonstrated by both the simulation and the experimental tests taken on 3D printed chains.

3D surface classification is a fundamental problem in computer vision and computational geometry. Surfaces can be classified by different transformation groups. Traditional classification methods mainly use topological transformation groups and Euclidean transformation groups. We introduce a novel method to classify surfaces by conformal transformation groups. Conformal equivalent class is refiner than topological equivalent class and coarser than isometric equivalent class, making it suitable for practical classification purposes. For general surfaces, the gradient fields of conformal maps form a vector space, which has a natural structure invariant under conformal transformations. We present an algorithm to compute this conformal structure, which can be represented as matrices, and use it to classify surfaces. The result is intrinsic to the geometry, invariant to triangulation and insensitive to resolution. To the best

Finding a meaningful 1–1 correspondence between different data, such as images or surface data, has important applications in various fields. It involves the optimization of certain energy functionals over the space of all diffeomorphisms. This type of optimization problems (called the diffeomorphism optimization problems, DOPs) is especially challenging, since the bijectivity of the mapping has to be ensured. Recently, a method, called the Beltrami holomorphic flow (BHF), has been proposed to solve the DOP using quasi-conformal theories (Lui et al. in J Sci Comput 50(3):557–585, 2012). The optimization problem is formulated over the space of Beltrami coefficients (BCs), instead of the space of all diffeomorphisms. BHF iteratively finds a sequence of BCs associated with a sequence of diffeomorphisms, using the gradient descent method, to minimize the energy functional. The use of BCs effectively controls the smoothness and bijectivity of the mapping, and hence makes it easier to handle the constrained optimization problem. However, the algorithm is computationally expensive. In this paper, we propose an efficient splitting algorithm, based on the classical alternating direction method of multiplier (ADMM), to solve the DOP. The basic idea is to split the energy functional into two energy terms: one involves the BC whereas the other involves the quasi-conformal map. Alternating minimization scheme can then be applied to minimize the energy functional. The proposed method significantly speeds up the previous BHF approach. It also extends the previous BHF algorithm to Riemann surfaces of arbitrary topologies, such as multiply-connected shapes. Experiments have been carried out on synthetic together with real surface data, which demonstrate the efficiency and efficacy of the proposed algorithm to solve the DOP.

A structured light system for three-dimensional shape measurement with single camera has the shortcoming of camera occlusion. To alleviate this problem, this paper introduces a structured light system with dual cameras for three-dimensional shape measurement. We discuss (1) system description, (2) system calibration, (3) three-dimensional data registration using the iterative closest-point (ICP) algorithm, and (4) three-dimensional data merging using holoimage. The principle of the system is introduced, and experiments are presented to verify its performance.

In medical imaging, parameterized 3D surface models are of great interest for anatomical modeling and visualization, statistical comparisons of anatomy, and surface-based registration and signal processing. Here we introduce a parameterization method based on algebraic functions. By solving the Yamabe equation with the Ricci flow method, we can conformally map a brain surface to a multi-hole disk. The resulting parameterizations do not have any singularities and are intrinsic and stable. To illustrate the technique, we computed parameterizations of several types of anatomical surfaces in MRI scans of the brain, including the hippocampi and the cerebral cortices with various landmark curves labeled. For the cerebral cortical surfaces, we show the parameterization results are consistent with selected landmark curves and can be matched to each other using constrained harmonic maps. Unlike previous