We prove that the higher harmonic signature of an even dimensional oriented Riemannian foliation F of a compact Riemannian
manifold M with coefficients in a leafwise U(p, q)-flat complex bundle is a leafwise homotopy invariant. We also prove the leafwise
homotopy invariance of the twisted higher Betti classes. Consequences for the Novikov conjecture for foliations and for groups are investigated.