No abstract uploaded!

Motivated by reformulating Furstenberg's $\times p,\times q$ conjecture via representations of a crossed product $C^*$-algebra, we show that in a discrete $C^*$-dynamical system $(A,\Gamma)$, the space of (ergodic) $\Gamma$-invariant states on $A$ is homeomorphic to a subspace of (pure) state space of $A\rtimes\Gamma$. Various applications of this in topological dynamical systems and representation theory are obtained. In particular, we prove that the classification of ergodic $\Gamma$-invariant regular Borel probability measures on a compact Hausdorff space $X$ is equivalent to the classification a special type of irreducible representations of $C(X)\rtimes \Gamma$.

No abstract uploaded!

We study the general problem of equidistribution of expanding translates of an analytic curve by an algebraic diagonal flow on the homogeneous space of a semisimple algebraic group G. We define two families of algebraic subvarieties of the associated partial flag variety, which give the obstructions to non-divergence and equidistribution. We apply this to prove that for Lebesgue almost every point on an analytic curve in the space of m × n real matrices whose image is not contained in any subvariety coming from these two families, Dirichlet’s theorem on simultaneous Diophantine approximation cannot be improved. The proof combines geometric invariant theory, Ratner’s theorem on measure rigidity for unipotent flows, and linearization technique.

Modeling cell differentiation from omics data is an essential problem in systems biology research. Although many algorithms have been established to analyze scRNA-seq data, approaches to infer the pseudo-time of cells or quantify their potency have not yet been satisfactorily solved. Here, we propose the Landscape of Differentiation Dynamics (LDD) method, which calculates cell potentials and constructs their differentiation landscape by a continuous birth-death process from scRNA-seq data. From the viewpoint of stochastic dynamics, we exploited the features of the differentiation process and quantified the differentiation landscape based on the source-sink diffusion process. In comparison with other scRNA-seq methods in seven benchmark datasets, we found that LDD could accurately and efficiently build the evolution tree of cells with pseudo-time, in particular quantifying their differentiation landscape in terms of potency. This study provides not only a computational tool to quantify cell potency or the Waddington potential landscape based on scRNA-seq data, but also novel insights to understand the cell differentiation process from a dynamic perspective.