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We present a 3D topological picture-language for quantum information. Our approach combines charged excitations carried by strings, with topological properties that arise from embedding the strings in the interior of a 3D manifold with boundary. A quon is a composite that acts as a particle. Specifically, a quon is a hemisphere containing a neutral pair of open strings with opposite charge. We interpret multiquons and their transformations in a natural way. We obtain a type of relation, a string–genus “joint relation,” involving both a string and the 3D manifold. We use the joint relation to obtain a topological interpretation of the C* Hopf algebra relations, which are widely used in tensor networks. We obtain a 3D representation of the controlled NOT (CNOT) gate that is considerably simpler than earlier work, and a 3D topological protocol for teleportation.

Topological qauntum field theory(TQFT) is a very powerful theoretical tool to study topological phases and phase transitions. In 2+1D, it is well known that the Chern-Simons theory captures all the universal topological data of topological phases, e.g., quasi-particle braiding statistics, chiral central charge and even provides us a deep insight for the nature of topological phase transitions. Recently, topological phases of quantum matter are also intensively studied in 3+1D and it has been shown that loop like excitation obeys the so-called three-loop-braiding statistics. In this paper, we will try to establish a TQFT framework to understand the quantum statistics of particle and loop like excitation in 3+1D. We will focus on Abelian topological phases for simplicity, however, the general framework developed here is not limited to Abelian topological phases.

Let V⊆A be a conformal inclusion of vertex operator algebras and let C be a category of grading-restricted generalized V-modules that admits the vertex algebraic braided tensor category structure of Huang-Lepowsky-Zhang. We give conditions under which C inherits semisimplicity from the category of grading-restricted generalized A-modules in C, and vice versa. The most important condition is that A be a rigid V-module in C with non-zero categorical dimension, that is, we assume the index of V as a subalgebra of A is finite and non-zero. As a consequence, we show that if A is strongly rational, then V is also strongly rational under the following conditions: A contains V as a V-module direct summand, V is C_2-cofinite with a rigid tensor category of modules, and A has non-zero categorical dimension as a V-module. These results are vertex operator algebra interpretations of theorems proved for general commutative algebras in braided tensor categories. We also generalize these results to the case that A is a vertex operator superalgebra.

The stochasticity of gene expression is manifested in the fluctuations of mRNA and protein copy numbers within a cell lineage over time. While data of this type can be obtained for many generations, most mathematical models are unsuitable to interpret such data since they assume non-growing cells. Here we develop a theoretical approach that quantitatively links the frequency content of lineage data to subcellular dynamics. We elucidate how the position, height, and width of the peaks in the power spectrum provide a distinctive fingerprint that encodes a wealth of information about mechanisms controlling transcription, translation, replication, degradation, bursting, promoter switching, cell cycle duration, cell division, gene dosage compensation, and cell size homeostasis. Predictions are confirmed by analysis of single-cell Escherichia coli data obtained using fluorescence microscopy. Furthermore, by matching the experimental and theoretical power spectra, we infer the temperature-dependent gene expression parameters, without the need of measurements relating fluorescence intensities to molecule numbers.