We construct a generalization of twistor spaces of hypercomplex manifolds and hyper-Kahler manifolds M, by generalizing the twistor P1 to a more general complex manifold Q. The resulting manifold X is complex if and only if Q admits a holomorphic map to P1. We make branched double covers of these manifolds. Some class of these branched double covers can give rise to non-Kahler Calabi-Yau manifolds. We show that these manifolds X and their branched double covers are non-Kahler. In the cases that Q is a balanced manifold, the resulting manifold X and its special branched double cover have balanced Hermitian metrics.

The stochasticity of gene expression is manifested in the fluctuations of mRNA and protein copy numbers within a cell lineage over time. While data of this type can be obtained for many generations, most mathematical models are unsuitable to interpret such data since they assume non-growing cells. Here we develop a theoretical approach that quantitatively links the frequency content of lineage data to subcellular dynamics. We elucidate how the position, height, and width of the peaks in the power spectrum provide a distinctive fingerprint that encodes a wealth of information about mechanisms controlling transcription, translation, replication, degradation, bursting, promoter switching, cell cycle duration, cell division, gene dosage compensation, and cell size homeostasis. Predictions are confirmed by analysis of single-cell Escherichia coli data obtained using fluorescence microscopy. Furthermore, by matching the experimental and theoretical power spectra, we infer the temperature-dependent gene expression parameters, without the need of measurements relating fluorescence intensities to molecule numbers.

This paper presents a 2×2 dynamical system to study the cyclic appearance and disappearance of the gas phase in a two-component (CO2, H2O), two phase (gas, liquid) flow in a single pore. Depending on injection rate, linearization of the dynamical system around equilibrium shows that the gas phase can exhibit two behaviors, either cyclically vanishing and appearing, or approaching a steady-state volume value. Numerical simulations were also run on the fully non-linear dynamical system to verify the results of the linearized model.

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The positive mass theorem states that for a nontrivial isolated physical system, the total energy, which includes contributions from both matter and gravitation is positive. This assertion was demonstrated in our previous paper in the important case when the space-time admits a maximal slice. Here this assumption is removed and the general theorem is demonstrated. Abstracts of the results of this paper appeared in [11] and [13].