The stochasticity of gene expression is manifested in the fluctuations of mRNA and protein copy numbers within a cell lineage over time. While data of this type can be obtained for many generations, most mathematical models are unsuitable to interpret such data since they assume non-growing cells. Here we develop a theoretical approach that quantitatively links the frequency content of lineage data to subcellular dynamics. We elucidate how the position, height, and width of the peaks in the power spectrum provide a distinctive fingerprint that encodes a wealth of information about mechanisms controlling transcription, translation, replication, degradation, bursting, promoter switching, cell cycle duration, cell division, gene dosage compensation, and cell size homeostasis. Predictions are confirmed by analysis of single-cell Escherichia coli data obtained using fluorescence microscopy. Furthermore, by matching the experimental and theoretical power spectra, we infer the temperature-dependent gene expression parameters, without the need of measurements relating fluorescence intensities to molecule numbers.

We explore various 4d Yang-Mills gauge theories (YM) living as boundary conditions of 5d gapped short/long-range entangled (SRE/LRE) topological states. Specifically, we explore 4d time-reversal symmetric pure YM of an SU(2) gauge group with a second-Chern-class topological term at θ=π (SU(2)θ=π YM). Its higher 't Hooft anomalies of generalized global symmetries indicate that the 4d SU(2)θ=π YM, in order to realize all global symmetries locally, necessarily couples to a 5d higher symmetry-protected topological state (SPTs, as an invertible TQFT, or as a 5d 1-form-center-symmetry-protected interacting "topological superconductor" in condensed matter). We revisit the 4d SU(2)θ=π YM-5d SRE-higher-SPTs coupled systems in [arXiv:1812.11968] and find their "Fantastic Four Siblings" with four sets of new higher anomalies associated with the Kramers singlet/doublet and bosonic/fermionic properties of Wilson lines. Following Weyl's gauge principle, by dynamically gauging the 1-form center symmetry, we transform a 5d bulk SRE SPTs into an LRE symmetry-enriched topologically ordered state (SETs); thus we obtain the 4d SO(3)θ=π YM-5d LRE-higher-SETs coupled system with dynamical higher-form gauge fields. Apply the tool introduced in [arXiv:1612.09298], we derive new exotic anyonic statistics of extended objects such as 2-worldsheet of strings and 3-worldvolume of branes, which physically characterize the 5d SETs. We discover new triple and quadruple link invariants potentially associated with the underlying 5d higher-gauge TQFTs, hinting a new intrinsic relation between non-supersymmetric 4d pure YM and topological links in 5d. We provide lattice simplicial complex regularizations and "condensed matter" realizations.

We derive a universal formula for the asymptotic growth of the mean value of three-point coefficient for Warped Conformal Field Theories (WCFTs), and provide a holographic calculation in BTZ black holes. WCFTs are two dimensional quantum field theories featuring a chiral Virasoro and U(1) Kac-Moody algebra, and are conjectured to be holographically dual to quantum gravity on asymptotically AdS3 spacetime with Compere-Song-Strominger boundary conditions. The WCFT calculation amounts to the calculation of one-point functions on torus, whose high temperature limit can be approximated by using modular covariance of WCFT, similar to the derivation of Cardy formula. The bulk process is given by a tadpole diagram, with a massive spinning particle propagates from the infinity to the horizon, and splits into particle and antiparticle which annihilate after going around the horizon of BTZ black holes. The agreement between the bulk and WCFT calculations indicates that the black hole geometries in asymptotically AdS3 spacetimes can emerge upon coarse-graining over microstates in WCFTs, similar to the results of Kraus and Maloney in the context of AdS/CFT.

The internal space of a N = 4 supersymmetric model with WessZumino term has a connection with totally skew-symmetric torsion and holonomy in SP(<i>n</i>). We study the mathematical background of this type of connection. In particular, we relate it to classical Hermitian geometry, construct homogeneous as well as inhomogeneous examples, characterize it in terms of holomorphic data, develop its potential theory and reduction theory.

Extremal but non-supersymmetric charged black holes with SU(2)_L spin in IIB string theory compactified to five dimensions on K^3 x S^1 are considered. These have a near-horizon or NHEK region with an enhanced SL(2,R)_L conformal symmetry. It is shown that the NHEK geometry has a second, inequivalent, asymptotically flat extension in which the radius of the S^1 becomes infinite but the radius of the angular circles of SU(2)_L orbits approach a constant. The asymptotic charges associated to the second solution identify it as a 5D D1-D5-Taub-NUT black string with certain nonzero worldvolume charge densities, temperatures and chemical potentials. The dual of the NHEK geometry is then identified as an IR limit of this wrapped brane configuration.