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The stochasticity of gene expression is manifested in the fluctuations of mRNA and protein copy numbers within a cell lineage over time. While data of this type can be obtained for many generations, most mathematical models are unsuitable to interpret such data since they assume non-growing cells. Here we develop a theoretical approach that quantitatively links the frequency content of lineage data to subcellular dynamics. We elucidate how the position, height, and width of the peaks in the power spectrum provide a distinctive fingerprint that encodes a wealth of information about mechanisms controlling transcription, translation, replication, degradation, bursting, promoter switching, cell cycle duration, cell division, gene dosage compensation, and cell size homeostasis. Predictions are confirmed by analysis of single-cell Escherichia coli data obtained using fluorescence microscopy. Furthermore, by matching the experimental and theoretical power spectra, we infer the temperature-dependent gene expression parameters, without the need of measurements relating fluorescence intensities to molecule numbers.

The presence of a massive scalar field near a Kerr black hole is known to produce instabilities associated with bound superradiant modes. In this paper we show that for massive fermions, rather than inducing an instability, the bound superradiant modes condense and form a Fermi sea which extends well outside the ergosphere. The shape of this Fermi sea in phase space and various other properties are analytically computed in the semiclassical WKB approximation. The low energy effective theory near the black hole is described by ripples in the Fermi surface. Expressions are derived for their dispersion relation and the effective force on particles which venture into the sea.

We exam the validity of the definition of the ADM angular momentum without the parity assumption. Explicit examples of asymptotically flat hypersurfaces in the Minkowski spacetime with zero ADM energy-momentum vector and finite non-zero angular momentum vector are presented. We also discuss the Beig-\'O Murchadha-Regge-Teitelboim center of mass and study analogous examples in the Schwarzschild spacetime

This is the second part of a three part series of papers. In this paper, we consider a general class of $N\times N$ random band matrices $H=(H_{ij})$ whose entries are centered random variables, independent up to a symmetry constraint. We assume that the variances $\mathbb E |H_{ij}|^2$ form a band matrix with typical band width $1\ll W\ll N$. We consider the generalized resolvent of $H$ defined as $G(Z):=(H - Z)^{-1}$, where $Z$ is a deterministic diagonal matrix such that $Z_{ij}=\left(z\mathds{1}_{1\le i \le W}+\wt z\mathds{1}_{ i > W} \right) \delta_{ij}$, with two distinct spectral parameters $z\in \mathbb C_+:=\{z\in \mathbb C:\im z>0\}$ and $\wt z\in \mathbb C_+\cup \mathbb R$. In this paper, we prove a sharp bound for the local law of the generalized resolvent $G$ for $W\gg N^{3/4}$. This bound is a key input for the proof of delocalization and bulk universality of random band matrices in [2]. Our proof depends on a fluctuations averaging bound on certain averages of polynomials in the resolvent entries, which will be proved in [10].