Estimation of longitudinal data covariance structure poses significant challenges because the data usually are collected at irregular time points. A viable semiparametric model for covariance matrixes has been proposed that allows one to estimate the variance function nonparametrically and to estimate the correlation function parametrically by aggregating information from irregular and sparse data points within each subject. But the asymptotic properties of the quasi-maximum likelihood estimator (QMLE) of parameters in the covariance model are largely unknown. We address this problem in the context of more general models for the conditional mean function, including parametric, nonparametric, or semiparametric. We also consider the possibility of rough mean regression function and introduce the difference-based method to reduce biases in the context of varying-coefficient partially linear mean regression

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Variable selection is vital to statistical data analyses. Many of procedures in use are ad hoc stepwise selection procedures, which are computationally expensiveandignore stochastic errors in the variable selection process of previous steps. An automatic and simultaneous variable selection procedure can be obtained by using a penalized likelihood method. In traditional linear models, the best subset selection and stepwise deletion methods coincide with a penalized leastsquares method when design matrices are orthonormal. In this paper, we propose a few new approaches to selecting variables for linear models, robust regression models and generalized linear models based on a penalized likelihood approach. A family of thresholding functions are proposed. The LASSO proposed by Tibshirani (1996) is a member of the penalized leastsquares with the # #-penalty. A smoothly clipped absolute deviation (SCAD) penalty function is introduced to ameliorate the properties of # #-penalty. A unied algorithm is introduced, which is backed up by statistical theory. The new approaches are compared with the ordinary leastsquares methods, the garrote method by Breiman (1995) and the LASSO method by Tibshirani (1996). Our simulation results show that the newly proposed methods compare favorably with other approaches as an automatic variable selection technique. Because of simultaneous selection of variables and estimation of parameters, we are able to give a simple estimated standard error formula, which is tested to be accurate enough for practical applications. Two real data examples illustrate the versatility and eectiveness of the

In this paper, we study, in some new ways, the estimation of unimodal densities. Several methods for estimating unimodal densities are proposed: plug-in MLE, pregrouping techniques, linear spline MLE. Based on the maximum likelihood method, an automatic procedure for estimating a unimodal density as well as its mode is proposed. We also give asymptotic theory for the proposed estimators. An important consequence of this study is that having to estimate the location of a mode does not affect the limiting behavior of the proposed unimodal density estimate. Simulation studies illustrate the proposed methods.

Motivated by recent work on studying massive imaging data in various neuroimaging studies, we propose a novel spatially varying coefficient model (SVCM) to capture the varying association between imaging measures in a three-dimensional volume (or two-dimensional surface) with a set of covariates. Two stylized features of neuorimaging data are the presence of multiple piecewise smooth regions with unknown edges and jumps and substantial spatial correlations. To specifically account for these two features, SVCM includes a measurement model with multiple varying coefficient functions, a jumping surface model for each varying coefficient function, and a functional principal component model. We develop a three-stage estimation procedure to simultaneously estimate the varying coefficient functions and the spatial correlations. The estimation procedure includes a fast multiscale adaptive estimation and