Technological innovations have revolutionized the process of scientific research and knowledge discovery. The availability of massive data and challenges from frontiers of research and development have reshaped statistical thinking, data analysis and theoretical studies. The challenges of high-dimensionality arise in diverse fields of sciences and the humanities, ranging from computational biology and health studies to financial engineering and risk management. In all of these fields, variable selection and feature extraction are crucial for knowledge discovery. We first give a comprehensive overview of statistical challenges with high dimensionality in these diverse disciplines. We then approach the problem of variable selection and feature extraction using a unified framework: penalized likelihood methods. Issues relevant to the choice of penalty functions are addressed. We demonstrate that for a host of statistical problems, as long as the dimensionality is not excessively large, we can estimate the model parameters as well as if the best model is known in advance. The persistence property in risk minimization is also addressed. The applicability of such a theory and method to diverse statistical problems is demonstrated. Other related problems with high-dimensionality are also discussed.

I would like to congratulate Professor Antoniadis for successfully outlining the current state-of-art of wavelet applications in statistics. Since wavelet techniques were introduced to statistics in the early 90s, the applications of wavelet techniques have mushroomed. There is a vast forest of wavelet theory and techniques in statistics and one can find himself easily lost in the jungle. The review by Antoniadis, ranging from linear wavelets to nonlinear wavelets, addressing both theoretical issues and practical relevance, gives in-depth coverage of the wavelet applications in statistics and guides one entering easily into the realm of wavelets.

The problem of estimating the density function and the regression function involving errors-in-variables in time series is considered. Under appropriate conditions, it is shown that the rates obtained in Fan (1991), Fan and Truong (1990) are also achievable in the context of dependent observations. Consequently, the results presented here extend our previous results for cross-sectional data to the longitudinal ones. oAbbreviated title. Measurement Errors in Time Series AMS 1980 subject classification. Primary 62G20. Secondary 62G05, 62J99.

There are few techniques available for testing whether or not a family of parametric times series models fits a set of data reasonably well without serious restrictions on the forms of alternative models. In this paper, we consider generalised likelihood ratio tests of whether or not the spectral density function of a stationary time series admits certain parametric forms. We propose a bias correction method for the generalised likelihood ratio test of Fan et al. (2001). In particular, our methods can be applied to test whether or not a residual series is white noise. Sampling properties of the proposed tests are established. A bootstrap approach is proposed for estimating the null distribution of the test statistics. Simulation studies investigate the accuracy of the proposed bootstrap estimate and compare the power of the various ways of constructing the generalised likelihood ratio tests as well as some classic methods like

Estimation of longitudinal data covariance structure poses significant challenges because the data usually are collected at irregular time points. A viable semiparametric model for covariance matrixes has been proposed that allows one to estimate the variance function nonparametrically and to estimate the correlation function parametrically by aggregating information from irregular and sparse data points within each subject. But the asymptotic properties of the quasi-maximum likelihood estimator (QMLE) of parameters in the covariance model are largely unknown. We address this problem in the context of more general models for the conditional mean function, including parametric, nonparametric, or semiparametric. We also consider the possibility of rough mean regression function and introduce the difference-based method to reduce biases in the context of varying-coefficient partially linear mean regression