Several new tests are proposed for examining the adequacy of a family of parametric models against large nonparametric alternatives. These tests formally check if the bias vector of residuals from parametric fits is negligible by using the adaptive Neyman test and other methods. The testing procedures formalize the traditional model diagnostic tools based on residual plots. We examine the rates of contiguous alternatives that can be detected consistently by the adaptive Neyman test. Applications of the procedures to the partially linear models are thoroughly discussed. Our simulation studies show that the new testing procedures are indeed powerful and omnibus. The power of the proposed tests is comparable to the <i>F</i>-test statistic even in the situations where the <i>F</i> test is known to be suitable and can be far more powerful than the <i>F</i>-test statistic in other situations. An application to testing linear models versus

Semiparametric regression models are very useful for longitudinal data analysis. The complexity of semiparametric models and the structure of longitudinal data pose new challenges to parametric inferences and model selection that frequently arise from longitudinal data analysis. In this article, two new approaches are proposed for estimating the regression coefficients in a semiparametric model. The asymptotic normality of the resulting estimators is established. An innovative class of variable selection procedures is proposed to select significant variables in the semiparametric models. The proposed procedures are distinguished from others in that they simultaneously select significant variables and estimate unknown parameters. Rates of convergence of the resulting estimators are established. With a proper choice of regularization parameters and penalty functions, the proposed variable selection procedures

This paper discusses statistical methods for estimating complex correlation structure from large pharmacogenomic datasets. We selectively review several prominent statistical methods for estimating large covariance matrix for understanding correlation structure, inverse covariance matrix for network modeling, large-scale simultaneous tests for selecting significantly differently expressed genes and proteins and genetic markers for complex diseases, and high dimensional variable selection for identifying important molecules for understanding molecule mechanisms in pharmacogenomics. Their applications to gene network estimation and biomarker selection are used to illustrate the methodological power. Several new challenges of Big data analysis, including complex data distribution, missing data, measurement error, spurious correlation, endogeneity, and the need for robust statistical methods, are also discussed.

This article proposes a consistent and efficient estimator of the high-frequency covariance (quadratic covariation) of two arbitrary assets, observed asynchronously with market microstructure noise. This estimator is built on the marriage of the quasimaximum likelihood estimator of the quadratic variation and the proposed generalized synchronization scheme and thus is not influenced by the Epps effect. Moreover, the estimation procedure is free of tuning parameters or bandwidths and is readily implementable. Monte Carlo simulations show the advantage of this estimator by comparing it with a variety of estimators with specific synchronization methods. The empirical studies of six foreign exchange future contracts illustrate the time-varying correlations of the currencies during the 2008 global financial crisis, demonstrating the similarities and differences in their roles as key currencies in the global market.

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