In pattern-forming developmental systems, cells commonly interpret graded input signals, known as morphogens. Morphogens often pattern tissues through cascades of sequential gene expression steps. Such a multi-tiered structure appears to constitute suboptimal use of the positional information provided by the input morphogen because noise is added at each tier. However, the conventional theory neglects the role of the format in which information is encoded. We argue that the relevant performance measure is not solely the amount of information carried by the morphogen, but the amount of information that can be accessed by the downstream network. We demonstrate that quantifying the information that is accessible to the system naturally explains the prevalence of multi-tiered network architectures as a consequence of the noise inherent to the control of gene expression. We support our argument with empirical observations from patterning along the major body axis of the fruit fly embryo.

We prove a compactness principle for the anisotropic formulation of the Plateau’s problem in codimension one, along the same lines of previous works of the authors [DGM14, DPDRG15]. In particular, we perform a new strategy for proving the rectifiability of the minimal set, avoiding the Preiss’ Rectifiability Theorem.

In this paper, we study the relation between topological orders and their gapped boundaries. We propose that the bulk for a given gapped boundary theory is unique. It is actually a consequence of a microscopic definition of a local topological order, which is a (potentially anomalous) topological order defined on an open disk. Using this uniqueness, we show that the notion of “bulk” is equivalent to the notion of center in mathematics. We achieve this by first introducing the notion of a morphism between two local topological orders of the same dimension, then proving that the bulk satisfying the same universal property as that of the center in mathematics. We propose a classification (formulated as a macroscopic definition of n+1D local topological orders by unitary multi-fusion n-categories, and explain that the notion of a morphism between two local topological orders is compatible with that of a unitary monoidal n-functor in a few low dimensional cases. We also explain in some low dimensional cases that this classification is compatible with the result of “bulk = center”. In the end, we explain that above boundary-bulk relation is only the first layer of a hierarchical structure which can be summarized by the functoriality of the bulk (or center). This functoriality also provides the physical meanings of some well-known mathematical results on fusion 1-categories. This work can also be viewed as the first step towards a systematic study of the category of local topological orders, and the boundary-bulk relation actually provides a useful tool for this study.

We initiate the study of M-strings in the thermodynamic limit. In this limit the BPS partition function of M5 branes localizes on configurations with a large number of strings which leads to a reformulation of the partition function in terms of a matrix model. We solve this matrix model and obtain its spectral curve which can be interpreted as the Seiberg-Witten curve associated to the compactified M5 brane theory.

We show existence and uniqueness of solutions to the Monge-Ampere equation on compact almost complex manifolds with non-integrable almost complex structure.