In this paper we study the ($L$^{$p$}($u$^{$p$}),$L$^{$q$}($v$^{$q$})) boundedness of the higher order commutators$T$_{$Ω,α,b$}^{$m$}and$M$_{$Ω,α,b$}^{$m$}formed by the fractional integral operator$T$_{$Ω,α$}, the fractional maximal operator$M$_{$Ω,α$}, and a function$b(x)$in BMO($v$), respectively.