In this paper, we study the zero loci of local systems of the form \delta\Pi , where \delta\Pi is the period sheaf of the universal family of CY hypersurfaces in a suitable ambient space \delta\Pi , and \delta\Pi is a given differential operator on the space of sections \delta\Pi . Using earlier results of three of the authors and their collaborators, we give several different descriptions of the zero locus of \delta\Pi . As applications, we prove that the locus is algebraic and in some cases, non-empty. We also give an explicit way to compute the polynomial defining equations of the locus in some cases. This description gives rise to a natural stratification to the zero locus.