Tautological systems developed in [8, 9] are Picard-Fuchs type systems to study period integrals of complete intersections in Fano varieties. We generalize tautological systems to zero loci of global sections of vector bundles. In particular, we obtain similar criterion as in [8, 9] about holonomicity and regularity of the systems. We also prove solution rank formulas and geometric realizations of solutions following the work on hypersurfaces in homogeneous varieties [4].