Heterogeneity is an unwanted variation when analyzing aggregated datasets from multiple sources. Though different methods have been proposed for heterogeneity adjustment, no systematic theory exists to justify these methods. In this work, we propose a generic framework named ALPHA (short for Adaptive Low-rank Principal Heterogeneity Adjustment) to model, estimate, and adjust heterogeneity from the original data. Once the heterogeneity is adjusted, we are able to remove the batch effects and to enhance the inferential power by aggregating the homogeneous residuals from multiple sources. Under a pervasive assumption that the latent heterogeneity factors simultaneously affect a fraction of observed variables, we provide a rigorous theory to justify the proposed framework. Our framework also allows the incorporation of informative covariates and appeals to the Bless of Dimensionality. As an illustrative

Many statistical models seek relationship between variables via subspaces of reduced dimensions. For instance, in factor models, variables are roughly distributed around a low dimensional subspace determined by the loading matrix; in mixed linear regression models, the coefficient vectors for different mixtures form a subspace that captures all regression functions; in multiple index models, the effect of covariates is summarized by the effective dimension reduction space.

We prove a sharp Bernstein inequality for general-state-space and not necessarily reversible Markov chains. It is sharp in the sense that the variance proxy term is optimal. Our result covers the classical Bernstein's inequality for independent random variables as a special case.

Suppose we lhave n observationis ftom Y= X+ c, where e is nieasuremiienit error with kiowin distributioni, and the denesity f of X is uniknowii withi thte nloln-paraniietric conistrainit

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