A general framework for constructions of endoscopy correspondences via automorphic integral transforms for classical groups is formulated in terms of the Arthur classification of the discrete spectrum of square-integrable automorphic forms, which is called the Principle of Endoscopy Correspondences, extending the well-known Howe Principle of Theta Correspondences. This suggests another principle, called the (τ, b)-theory of automorphic forms of classical groups, to reorganize and extend the series of work of Piatetski- Shapiro, Rallis, Kudla and others on standard L-functions of classical groups and theta correspondence.

Adult stem cells, which exist throughout the body, multiply by cell division to replenish dying cells or to promote regeneration to repair damaged tissues. To perform these functions during the lifetime of organs or tissues, stem cells need to maintain their populations in a faithful distribution of their epigenetic states, which are suscepti- ble to stochastic fluctuations during each cell division, unexpected injury, and potential genetic mutations that occur during many cell divisions. However, it remains unclear how the three processes of differentiation, proliferation, and apoptosis in regulating stem cells collectively manage these challenging tasks. Here, without consid- ering molecular details, we propose a genetic optimal control model for adult stem cell regeneration that includes the three fundamental processes, along with cell division and adaptation based on differ- ential fitnesses of phenotypes. In the model, stem cells with a distri- bution of epigenetic states are required to maximize expected performance after each cell division. We show that heteroge- neous proliferation that depends on the epigenetic states of stem cells can improve the maintenance of stem cell distributions to create balanced populations. A control strategy during each cell division leads to a feedback mechanism involving heterogeneous proliferation that can accelerate regeneration with less fluctuation in the stem cell population. When mutation is allowed, apoptosis evolves to maximize the performance during homeostasis after multiple cell divisions. The overall results highlight the importance of cross-talk between genetic and epigenetic regulation and the performance objectives during homeostasis in shaping a desirable heterogeneous distribution of stem cells in epigenetic states.

The approach combines second and fourth order statistics to perform BSS of instantaneous mixtures. It applies for any number of receivers if they are as many as sources. It is a batch algorithm that uses non-Gaussianity and stationarity of source signals. It is linear algebra based direct method, reliable and robust, though large dimensions of sources may slow down the computation significantly. It is however limited to instantaneous mixtures.

Let $\Omega $ be a bounded $C^2$ domain in $R^n$ and $\phi : \partial \Omega \to \mathbb{R}^m$ be a continuous map. The Dirichlet problem for the minimal surface system asks whether there exists a Lipschitz map $f : \Omega \to \mathbb{R}^m$ with $ f |_{\partial \Omega}$ and with the graph of $f$ a minimal submanifold in $R^{n+m}$. For $m = 1$, the Dirichlet problem was solved more than thirty years ago by Jenkins-Serrin [13] for any mean convex domains and the solutions are all smooth. This paper considers the Dirichlet problem for convex domains in arbitrary codimension $m$. We prove if $\psi : \bar{\Omega} \to \mathbb{R}^m$ satisfies $8n\delta sup_{\Omega}||D^2 \psi| + \sqrt{2} sup_{\partial \Omega} |D\psi| <1$, then the Dirichlet problem for $ \psi |_{\partial \Omega}$ is solvable in smooth maps. Here $\delta$ is the diameter of $\Omega$ . Such a condition is necessary in view of an example of Lawson-Osserman [15]. In order to prove this result, we study the associated parabolic system and solve the Cauchy-Dirichlet problem with $\psi$ as initial data.

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