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Adult stem cells, which exist throughout the body, multiply by cell division to replenish dying cells or to promote regeneration to repair damaged tissues. To perform these functions during the lifetime of organs or tissues, stem cells need to maintain their populations in a faithful distribution of their epigenetic states, which are suscepti- ble to stochastic fluctuations during each cell division, unexpected injury, and potential genetic mutations that occur during many cell divisions. However, it remains unclear how the three processes of differentiation, proliferation, and apoptosis in regulating stem cells collectively manage these challenging tasks. Here, without consid- ering molecular details, we propose a genetic optimal control model for adult stem cell regeneration that includes the three fundamental processes, along with cell division and adaptation based on differ- ential fitnesses of phenotypes. In the model, stem cells with a distri- bution of epigenetic states are required to maximize expected performance after each cell division. We show that heteroge- neous proliferation that depends on the epigenetic states of stem cells can improve the maintenance of stem cell distributions to create balanced populations. A control strategy during each cell division leads to a feedback mechanism involving heterogeneous proliferation that can accelerate regeneration with less fluctuation in the stem cell population. When mutation is allowed, apoptosis evolves to maximize the performance during homeostasis after multiple cell divisions. The overall results highlight the importance of cross-talk between genetic and epigenetic regulation and the performance objectives during homeostasis in shaping a desirable heterogeneous distribution of stem cells in epigenetic states.

Let $k$ be a field and $k(x_0,\ldots,x_{p-1})$ be the rational function field of $p$ variables over $k$ where $p$ is a prime number. Suppose that $G=\langle\sigma\rangle \simeq C_p$ acts on $k(x_0,\ldots,x_{p-1})$ by $k$-automorphisms defined as $\sigma:x_0\mapsto x_1\mapsto\cdots\mapsto x_{p-1}\mapsto x_0$. Denote by $P$ the set of all prime numbers and define $P_0=\{p\in P:\bm{Q}(\zeta_{p-1})$ is of class number one$\}$ where $\zeta_n$ a primitive $n$-th root of unity in $\bm{C}$ for a positive integer $n$; $P_0$ is a finite set by \cite{MM}. Theorem. Let $k$ be an algebraic number field and $P_k=\{p\in P: p$ is ramified in $k\}$. Then $k(x_0,\ldots,x_{p-1})^G$ is not stably rational over $k$ for all $p\in P\backslash (P_0\cup P_k)$.

We present a method for organizing a heterogeneous collection of 3D shapes for overview and exploration. Instead of relying on quantitative distances, which may become unreliable between dissimilar shapes, we introduce a qualitative analysis which utilizes multiple distance measures but only in cases where the measures can be reliably compared. Our analysis is based on the notion of quartets, each defined by two pairs of shapes, where the shapes in each pair are close to each other, but far apart from the shapes in the other pair. Combining the information from many quartets computed across a shape collection using several distance measures, we create a hierarchical structure we call categorization tree of the shape collection. This tree satisfies the topological (qualitative) constraints imposed by the quartets creating an effective organization of the shapes. We present categorization trees computed on various collections of shapes and compare them to ground truth data from human categorization. We further introduce the concept of degree of separation chart for every shape in the collection and show the effectiveness of using it for interactive shapes exploration.