Adult stem cells, which exist throughout the body, multiply by cell division to replenish dying cells or to promote regeneration to repair damaged tissues. To perform these functions during the lifetime of organs or tissues, stem cells need to maintain their populations in a faithful distribution of their epigenetic states, which are suscepti- ble to stochastic fluctuations during each cell division, unexpected injury, and potential genetic mutations that occur during many cell divisions. However, it remains unclear how the three processes of differentiation, proliferation, and apoptosis in regulating stem cells collectively manage these challenging tasks. Here, without consid- ering molecular details, we propose a genetic optimal control model for adult stem cell regeneration that includes the three fundamental processes, along with cell division and adaptation based on differ- ential fitnesses of phenotypes. In the model, stem cells with a distri- bution of epigenetic states are required to maximize expected performance after each cell division. We show that heteroge- neous proliferation that depends on the epigenetic states of stem cells can improve the maintenance of stem cell distributions to create balanced populations. A control strategy during each cell division leads to a feedback mechanism involving heterogeneous proliferation that can accelerate regeneration with less fluctuation in the stem cell population. When mutation is allowed, apoptosis evolves to maximize the performance during homeostasis after multiple cell divisions. The overall results highlight the importance of cross-talk between genetic and epigenetic regulation and the performance objectives during homeostasis in shaping a desirable heterogeneous distribution of stem cells in epigenetic states.

The spatially homogeneous Boltzmann equation without angular cutoff is discussed on the regularity of solutions for the modified hard potential and Debye-Yukawa potential. When the angular singularity of the cross section is moderate, any weak solution having the finite mass, energy and entropy lies in the Sobolev space of infinite order for any positive time, while for the general potentials, it lies in the Schwartz space if it has moments of arbitrary order. The main ingredients of the proof are the suitable choice of the mollifiers composed of pseudo-differential operators and the sharp estimates of the commutators of the Boltzmann collision operator and pseudo-differential operators. The method developed here also provides some new estimates on the collision operator.

We obtain two-sided sub-Gaussian estimates of heat kernels for strongly local Dirichlet forms on intervals, equipped with self-similar measures generated by iterated function systems (IFS's) that do not satisfy the open set condition (OSC) and have overlaps. We first give a framework for heat kernel estimates on intervals, and then consider examples of self-similar measures to illustrate this phenomenon. These examples include the infinite Bernoulli convolution associated with the golden ratio, and a family of convolutions of Cantor-type measures. We make use of Strichartz second-order identities defined by auxiliary IFS's to compute measures of cells on different levels. These auxiliary IFS's do satisfy the OSC and are used to define new metrics. The walk dimensions obtained under these new metrics are strictly greater than 2 and are closely related to the spectral dimension of fractal Laplacians.

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