In this note, we discuss the mean curvature flow of graphs of maps between Riemannian manifolds. Special emphasis will be placed on estimates of the flow as a non-linear parabolic system of differential equations. Several global existence theorems and applications to isotopy problems in geometry and topology will be presented. The results are based on joint works of the author with his collaborators I. Medo\v{s}, K. Smoczyk, and M.-P. Tsui.

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Let$X$be a rationally convex compact subset of the unit sphere$S$in ℂ^{2}, of three-dimensional measure zero. Denote by$R$($X$) the uniform closure on$X$of the space of functions$P$/$Q$, where$P$and$Q$are polynomials and$Q$≠0 on$X$. When does$R$($X$)=$C$($X$)?