We address the registration problem of genus-one surfaces (such as vertebrae bones) with prescribed landmark constraints. The high-genus topology of the surfaces makes it challenging to obtain a unique and bijective surface mapping that matches landmarks consistently. This work proposes to tackle this registration problem using a special class of quasi-conformal maps called Teichmüller maps (T-Maps). A landmark constrained T-Map is the unique mapping between genus-1 surfaces that minimizes the maximal conformality distortion while matching the prescribed feature landmarks. Existence and uniqueness of the landmark constrained T-Map are theoretically guaranteed. This work presents an iterative algorithm to compute the T-Map. The main idea is to represent the set of diffeomorphism using the Beltrami coefficients (BC). The BC is iteratively adjusted to an optimal one, which corresponds to our desired T-Map that matches the prescribed landmarks and satisfies the periodic boundary condition on the universal covering space. Numerical experiments demonstrate the effectiveness of our proposed algorithm. The method has also been applied to register vertebrae bones with prescribed landmark points and curves, which gives accurate surface registrations.
Fusion of images with same or different modalities has been conquering medical imaging field more rapidly due to the presence of highly accessible patients’ information in recent years. For example, cross platform non-rigid registration of CT with MRI images has found a significant role in different clinical application. In some instances labelling of anatomical features by medical experts are also involved to further improve the accuracy and authenticity of the registration. Being motivated
by these, we propose a new algorithm to compute diffeomorphic hybrid multi-modality registration with large deformations. Our iterative scheme consists of mainly two steps. First, we obtain the optimal Beltrami coefficient corresponding to the diffeomorphic mapping that exactly superimposes the feature points. The second step detects the intensity difference in the framework of mutual information. A non-rigid deformation which minimizes the intensity difference is then obtained. Experiments have been carried out on both synthetic and real data. Results demonstrate the stability and efficacy of the proposed algorithm to obtain diffeomorphic image registration.
This paper presents a method to compute the quasi-conformal parameterization (QCMC) for a multiply-connected 2D domain or surface. QCMC computes a quasi-conformal map from a multiply-connected domain S onto a punctured disk D_S associated with a given Beltrami differential. The Beltrami differential, which measures the conformality distortion, is a complex-valued function μ: S→ℂ with supremum norm strictly less than 1. Every Beltrami differential gives a conformal structure of S. Hence, the conformal module of D_S, which are the radii and centers of the inner circles, can be fully determined by μ, up to a Möbius transformation. In this paper, we propose an iterative algorithm to simultaneously search for the conformal module and the optimal quasi-conformal parameterization. The key idea is to minimize the Beltrami energy subject to the boundary constraints. The optimal solution is our desired quasi-conformal parameterization onto a punctured disk. The parameterization of the multiply-connected domain simplifies numerical computations and has important applications in various fields, such as in computer graphics and vision. Experiments have been carried out on synthetic data together with real multiply-connected Riemann surfaces. Results show that our proposed method can efficiently compute quasi-conformal parameterizations of multiply-connected domains and outperforms other state-of-the-art algorithms. Applications of the proposed parameterization technique have also been explored.
We propose a new method to obtain landmark-matching transformations between n-dimensional Euclidean spaces with large deformations. Given a set of feature correspondences, our algorithm searches for an optimal folding-free mapping that satisfies the prescribed landmark constraints. The standard conformality distortion defined for mappings between 2-dimensional spaces is first generalized to the n-dimensional conformality distortion K(f) for a mapping f between n-dimensional Euclidean spaces (n≥3). We then propose a variational model involving K(f) to tackle the landmark-matching problem in higher dimensional spaces. The generalized conformality term K(f) enforces the bijectivity of the optimized mapping and minimizes its local geometric distortions even with large deformations. Another challenge is the high computational cost of the proposed model. To tackle this, we have also proposed a numerical method to solve the optimization problem more efficiently. Alternating direction method with multiplier (ADMM) is applied to split the optimization problem into two subproblems. Preconditioned conjugate gradient method with multi-grid preconditioner is applied to solve one of the sub-problems, while a fixed-point iteration is proposed to solve another subproblem. Experiments have been carried out on both synthetic examples and lung CT images to compute the diffeomorphic landmark-matching transformation with different landmark constraints. Results show the efficacy of our proposed model to obtain a folding-free landmark-matching transformation between n-dimensional spaces with large deformations.
Alzheimer's disease (AD) is a no-cure disease that has been frustrating the scientists for many years. Analyzing the disease has become an important but challenging research topic. The shape analysis of the sub-cortical structure of AD patients has been commonly used to understand this disease. In this paper, we assess the feasibility of using shape information on the hippocampal (HP) surfaces to detect some sub-structural changes in AD patients. We propose a quasi-conformal statistical shape analysis model, which allows us to study local regional geometric changes in the HPs amongst normal control (NC) and AD groups. A shape index defined by the quasi-conformality and surface curvatures is used to characterize region-specific shape variations of the HP surfaces. Feature vectors can be extracted for each HPs, with which a classification model can be built using machine learning methods to classify HPs into NC and AD subjects. Experiments have been carried out on 99 normal controls and 41 patients with AD. Results demonstrate that the proposed quasi-conformal based model is effective for classifying HPs into NC and AD groups with high classification accuracy (with highest overall classification accuracy reaching 87.86% in a leave-one-out experiment using the whole dataset).