Wenlu YangShanghai Maritime UniversityRonald Lok Ming LuiHarvard UniversityJia-Hong GaoThe University of ChicagoTony F. ChanThe Hong Kong University of Science and TechnologyShing-Tung YauHarvard UniversityReisa A. SperlingHarvard UniversityXudong HuangHarvard University
Journal of Alzheimer's Disease, 24, (4), 775–783, 2011
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There is an unmet medical need to identify neuroimaging biomarkers that is able to accurately diagnose and monitor Alzheimer's disease (AD) at very early stages and assess the response to AD-modifying therapies. To a certain extent, volumetric and functional magnetic resonance imaging (fMRI) studies can detect changes in structure, cerebral blood flow and blood oxygenation that are able to distinguish AD and mild cognitive impairment (MCI) subjects from normal controls. However, it has been challenging to use fully automated MRI analytic methods to identify potential AD neuroimaging biomarkers. We have thus proposed a method based on independent component analysis (ICA), for studying potential AD-related MR image features, coupled with the use of support vector machine (SVM) for classifying scans into categories of AD, MCI, and normal control (NC) subjects. The MRI data were selected from Open Access Series of Imaging Studies (OASIS) and the Alzheimer's Disease Neuroimaging Initiative (ADNI) databases. The experimental results showed that our ICA-based method can differentiate AD and MCI subjects from normal controls, although further methodological improvement in the analytic method and inclusion of additional variables may be required for optimal classification.
Shi-Qing XinNanyang Technological UniversityYing HeNanyang Technological UniversityChi-Wing FuNanyang Technological UniversityDefeng WangThe Chinese University of Hong KongShi LinThe Chinese University of Hong KongWinnie C.W. ChuThe Chinese University of Hong KongJack C.Y. ChengThe Chinese University of Hong KongXianfeng GuStony Brook UniversityRonald Lok Ming LuiThe Chinese University of Hong Kong
Medical Image Computing and Computer-Assisted Intervention, 384-92, 2011
This paper proposes a novel algorithm to extract feature landmarks on the vestibular system (VS), for the analysis of Adolescent Idiopathic Scoliosis (AIS) disease. AIS is a 3-D spinal deformity commonly occurred in adolescent girls with unclear etiology. One popular hypothesis was suggested to be the structural changes in the VS that induce the disturbed balance perception, and further cause the spinal deformity. The morphometry of VS to study the geometric differences between the healthy and AIS groups is of utmost importance. However, the VS is a genus-3 structure situated in the inner ear. The high-genus topology of the surface poses great challenge for shape analysis. In this work, we present a new method to compute exact geodesic loops on the VS. The resultant geodesic loops are in Euclidean metric, thus characterizing the intrinsic geometric properties of the VS based on the real background geometry. This leads to more accurate results than existing methods, such as the hyperbolic Ricci flow method. Furthermore, our method is fully automatic and highly efficient, e.g., one order of magnitude faster than. We applied our algorithm to the VS of normal and AIS subjects. The promising experimental results demonstrate the efficacy of our method and reveal more statistically significant shape difference in the VS between right-thoracic AIS and normal subjects.
In this paper, we propose novel algorithms for inpainting and refinement of diffeomorphisms. We first represent a diffeomorphism by its Beltrami coefficient. Then it is possible to refine and inpaint the diffeomorphism by processing this Beltrami coefficient. With the inpainted/refined Beltrami coefficient, we construct a new diffeomorphism using the exact Beltrami holomorphic flow algorithm proposed in this paper. We apply our algorithms on several practical applications, which include the inpainting of a highly distorted diffeomorphism, the inpainting of image sequences of deforming shapes, the super-resolution of diffeomorphisms and the global parameterization of cortical surfaces by combining local parameterizations. Experiments show that our algorithm can solve these problems with natural and smooth results. We demonstrate how our proposed method can be widely applied in areas from texture mapping to video processing, and from computer graphics to medical imaging.
Ronald Lok Ming LuiHarvard UniversityTsz Wai WongUniversity of California at IrvineWei ZengStony Brook UniversityXianfeng GuStony Brook UniversityPaul M. ThompsonUniversity of Southern CaliforniaTony F. ChanThe Hong Kong University of Science and TechnologyShing-Tung YauHarvard University
Journal of Scientific Computing, 50, (3), 557-585, 2012.3
In shape analysis, finding an optimal 1-1 correspondence between 3D surfaces within a large class of admissible bijective mappings is of great importance. Such a process is called surface registration. The difficulty lies in the fact that the space of all surface diffeomorphisms is a complicated functional space, making it challenging to exhaustively search for the best mapping. To tackle this problem, we propose a simple representation of bijective surface maps using Beltrami coefficients (BCs)—complex-valued functions defined on surfaces with supremum norm less than 1. Fixing any 3 points on a pair of surfaces, there is a 1-1 correspondence between the set of surface diffeomorphisms between them and the set of BCs. Hence, every bijective surface map may be represented by a unique BC. Conversely, given a BC, we can reconstruct the unique surface map associated with it using the Beltrami Holomorphic flow (BHF) method. Using BCs to represent surface maps is advantageous because it is a much simpler functional space, which captures many essential features of a surface map. By adjusting BCs, we equivalently adjust surface diffeomorphisms to obtain the optimal map with desired properties. More specifically, BHF gives us the variation of the associated map under the variation of BC. Using this, a variational problem over the space of surface diffeomorphisms can be easily reformulated into a variational problem over the space of BCs. This makes the minimization procedure much easier. More importantly, the diffeomorphic property is always preserved. We test our method on synthetic examples and real medical applications. Experimental results demonstrate the effectiveness of our proposed algorithm for surface registration.
Wei ZengStony Brook UniversityRonald Lok Ming LuiThe Chinese University of Hong KongFeng LuoRutgers UniversityTony F. ChanThe Hong Kong University of Science and TechnologyShing-Tung YauHarvard UniversityXianfeng GuStony Brook University
Surface mapping plays an important role in geometric processing. They induce both area and angular distortions. If the angular distortion is bounded, the mapping is called a quasi-conformal map. Many surface maps in our physical world are quasi-conformal. The angular distortion of a quasi-conformal map can be represented by Beltrami differentials. According to quasi-conformal Teichmüller theory, there is an 1-1 correspondence between the set of Beltrami differentials and the set of quasi-conformal surface maps. Therefore, every quasi-conformal surface map can be fully determined by the Beltrami differential and can be reconstructed by solving the so-called Beltrami equation.
In this work, we propose an effective method to solve the Beltrami equation on general Riemann surfaces. The solution is a quasi-conformal map associated with the prescribed Beltrami differential. We firstly formulate a discrete analog of quasi-conformal maps on triangular meshes. Then, we propose an algorithm to compute discrete quasi-conformal maps. The main strategy is to define a discrete auxiliary metric of the source surface, such that the original quasi-conformal map becomes conformal under the newly defined discrete metric. The associated map can then be obtained by using the discrete Yamabe flow method. Numerically, the discrete quasi-conformal map converges to the continuous real solution as the mesh size approaches to 0. We tested our algorithm on surfaces scanned from real life with different topologies. Experimental results demonstrate the generality and accuracy of our auxiliary metric method.