Based on large N Chern-Simons/topological string duality, in a series of papers [36, 21, 19], Labastida, Marino, Ooguri, and
Vafa conjectured certain remarkable new algebraic structure of link invariants and the existence of infinite series of new integer
invariants. In this paper, we provide a proof of this conjecture. Moreover, we also show these new integer invariants vanish at large genera.