Variable selection in high-dimensional space characterizes many contemporary problems in scientific discovery and decision making. Many frequently-used techniques are based on independence screening; examples include correlation ranking (Fan & Lv, 2008) or feature selection using a two-sample t-test in high-dimensional classification (Tibshirani et al., 2003). Within the context of the linear model, Fan & Lv (2008) showed that this simple correlation ranking possesses a sure independence screening property under certain conditions and that its revision, called iteratively sure independent screening (ISIS), is needed when the features are marginally unrelated but jointly related to the response variable. In this paper, we extend ISIS, without explicit definition of residuals, to a general pseudo-likelihood framework, which includes generalized linear models as a special case. Even in the least-squares setting, the new method improves ISIS by allowing feature deletion in the iterative process. Our technique allows us to select important features in high-dimensional classification where the popularly used two-sample t-method fails. A new technique is introduced to reduce the false selection rate in the feature screening stage. Several simulated and two real data examples are presented to illustrate the methodology.

We discuss the difficulties of estimating quadratic functionals based on observations Y (t) from the white noise model Y (t) where Y (t) is a standard Wiener process on Y (t) . The optimal rates of convergence (as Y (t) ) for estimating quadratic functionals under certain geometric constraints are found. Specifically, the optimal rates of estimating Y (t) under hyperrectangular constraints Y (t) and weighted Y (t) -body constraints Y (t) are computed explicitly, where Y (t) is the Y (t) th Fourier-Bessel coefficient of the unknown function Y (t) . We develop lower bounds based on testing two highly composite hypercubes and address their advantages. The attainable lower bounds are found by applying the hardest one-dimensional approach as well as the hypercube method. We demonstrate that for estimating regular quadratic functionals [ie, the functionals which can be estimated

High-dimensional statistical tests often ignore correlations to gain simplicity and stability leading to null distributions that depend on functionals of correlation matrices such as their Frobenius norm and other r norms. Motivated by the computation of critical values of such tests, we investigate the difficulty of estimation the functionals of sparse correlation matrices. Specifically, we show that simple plug-in procedures based on thresholded estimators of correlation matrices are sparsity-adaptive and minimax optimal over a large class of correlation matrices. Akin to previous results on functional estimation, the minimax rates exhibit an elbow phenomenon. Our results are further illustrated in simulated data as well as an empirical study of data arising in financial econometrics.

Many data mining and statistical machine learning algorithms have been developed to select a subset of covariates to associate with a response variable. Spurious discoveries can easily arise in high-dimensional data analysis due to enormous possibilities of such selections. How can we know statistically our discoveries better than those by chance? In this paper, we define a measure of goodness of spurious fit, which shows how good a response variable can be fitted by an optimally selected subset of covariates under the null model, and propose a simple and effective LAMM algorithm to compute it. It coincides with the maximum spurious correlation for linear models and can be regarded as a generalized maximum spurious correlation. We derive the asymptotic distribution of such goodness of spurious fit for generalized linear models and L1 regression. Such an asymptotic distribution depends on the sample size, ambient dimension, the number of variables used in the fit, and the covariance information. It can be consistently estimated by multiplier bootstrapping and used as a benchmark to guard against spurious discoveries. It can also be applied to model selection, which considers only candidate models with goodness of fits better than those by spurious fits. The theory and method are convincingly illustrated by simulated examples and an application to the binary outcomes from German Neuroblastoma Trials.

We develop an expectation-maximization algorithm with local adaptivity for image segmentation and classification. The key idea of our approach is to combine global statistics extracted from the Gaussian mixture model or other proper statistical models with local statistics and geometrical information, such as local probability distribution, orientation, and anisotropy. The combined information is used to design an adaptive local classification strategy that improves the robustness of the algorithm and also keeps fine features in the image. The proposed methodology is flexible and can be easily generalized to deal with other inferred information/quantities and statistical methods/models.