There is an unmet medical need to identify neuroimaging biomarkers that allow us to accurately diagnose and monitor Alzheimer's disease (AD) at its very early stages and to assess the response to AD-modifying therapies. To a certain extent, volumetric and functional magnetic resonance imaging (fMRI) studies can detect changes in structure, cerebral blood flow, and blood oxygenation that distinguish AD and mild cognitive impairment (MCI) subjects from healthy control (HC) subjects. However, it has been challenging to use fully automated MRI analytic methods to identify potential AD neuroimaging biomarkers. We have thus proposed a method based on independent component analysis (ICA) for studying potential AD-related MR image features that can be coupled with the use of support vector machine (SVM) for classifying scans into categories of AD, MCI, and HC subjects. The MRI data were selected from

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The focus of this work is on rigorous mathematical analysis of the topological derivative based detection algorithms for the localization of an elastic inclusion of vanishing characteristic size. A filtered quadratic misfit is considered, and the performance of the topological derivative imaging functional resulting therefrom is analyzed. Our analysis reveals that the imaging functional may not attain its maximum at the location of the inclusion. Moreover, the resolution of the image is below the diffraction limit. Both phenomena are due to the coupling of pressure and shear waves propagating with different wave speeds and polarization directions. A novel imaging functional based on the weighted Helmholtz decomposition of the topological derivative is, therefore, introduced. It is thereby substantiated that the maximum of the imaging functional is attained at the location of the inclusion and the resolution is enhanced and proves to be the diffraction limit. Finally, we investigate the stability of the proposed imaging functionals with respect to measurement and medium noises.

In this paper, we will discuss some upper bound formulas for Ramsey numbers.At first, we will derive a more unified form from two parameter formulas which was obtained by Yiru Huang etc. Then, similar to their methods, we introduce two new bound formulas for Ramsey numbers in this paper. At last, as the applications of our new bound formulas, some upper bounds for small Ramsey numbers will be obtained.