We prove a formula which relates Euler characteristic of moduli spaces of stable pairs on local K3 surfaces to counting invariants of semistable sheaves on them. Our formula generalizes KawaiYoshioka’s formula for stable pairs with irreducible curve classes to arbitrary curve classes. We also propose a conjectural multiple cover formula of sheaf counting invariants which, combined with our main result, leads to an Euler characteristic version of KatzKlemm-Vafa conjecture for stable pairs.

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We construct a conformally invariant random family of closed curves in the plane by welding of random homeomorphisms of the unit circle. The homeomorphism is constructed using the exponential of$βX$, where X is the restriction of the 2-dimensional free field on the circle and the parameter$β$is in the “high temperature” regime $$ \beta < \sqrt {2} $$ . The welding problem is solved by studying a non-uniformly elliptic Beltrami equation with a random complex dilatation. For the existence a method of Lehto is used. This requires sharp probabilistic estimates to control conformal moduli of annuli and they are proven by decomposing the free field as a sum of independent fixed scale fields and controlling the correlations of the complex dilatation restricted to dyadic cells of various scales. For the uniqueness we invoke a result by Jones and Smirnov on conformal removability of Hölder curves. Our curves are closely related to SLE($ϰ$) for$ϰ$<4.

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There is an unmet medical need to identify neuroimaging biomarkers that is able to accurately diagnose and monitor Alzheimer's disease (AD) at very early stages and assess the response to AD-modifying therapies. To a certain extent, volumetric and functional magnetic resonance imaging (fMRI) studies can detect changes in structure, cerebral blood flow and blood oxygenation that are able to distinguish AD and mild cognitive impairment (MCI) subjects from normal controls. However, it has been challenging to use fully automated MRI analytic methods to identify potential AD neuroimaging biomarkers. We have thus proposed a method based on independent component analysis (ICA), for studying potential AD-related MR image features, coupled with the use of support vector machine (SVM) for classifying scans into categories of AD, MCI, and normal control (NC) subjects. The MRI data were selected from Open Access Series of Imaging Studies (OASIS) and the Alzheimer's Disease Neuroimaging Initiative (ADNI) databases. The experimental results showed that our ICA-based method can differentiate AD and MCI subjects from normal controls, although further methodological improvement in the analytic method and inclusion of additional variables may be required for optimal classification.