Local quasilikelihood estimation is a useful extension of local least squares methods, but its computational cost and algorithmic convergence problems make the procedure less appealing, particularly when it is iteratively used in methods such as the backfitting algorithm, crossvalidation and bootstrapping. A onestep local quasilikelihood estimator is introduced to overcome the computational drawbacks of the local quasilikelihood method. We demonstrate that as long as the initial estimators are reasonably good, the onestep estimator has the same asymptotic behaviour as the local quasilikelihood method. Our simulation shows that the onestep estimator performs at least as well as the local quasilikelihood method for a wide range of choices of bandwidths. A datadriven bandwidth selector is proposed for the onestep estimator based on the preasymptotic substitution method of Fan and Gijbels. It is

Estimation of longitudinal data covariance structure poses significant challenges because the data usually are collected at irregular time points. A viable semiparametric model for covariance matrixes has been proposed that allows one to estimate the variance function nonparametrically and to estimate the correlation function parametrically by aggregating information from irregular and sparse data points within each subject. But the asymptotic properties of the quasi-maximum likelihood estimator (QMLE) of parameters in the covariance model are largely unknown. We address this problem in the context of more general models for the conditional mean function, including parametric, nonparametric, or semiparametric. We also consider the possibility of rough mean regression function and introduce the difference-based method to reduce biases in the context of varying-coefficient partially linear mean regression

Macrophage activation and persistent inflammation contribute to the pathological process of spinal cord injury (SCI). It was reported that M2 macrophages were induced at 37 days after SCI but M2 markers were reduced or eliminated after 1 week. By contrast, M1 macrophage response is rapidly induced and then maintained at injured spinal cord. However, factors that modulate macrophage phenotype and function are poorly understood. We developed a model to distinguish bonemarrow derived macrophages (BMDMs) from residential microglia and explored how BMDMs change their phenotype and functions in response to the lesionrelated factors in injured spinal cord. Infiltrating BMDMs expressing higher Mac2 and lower CX3CR1 migrate to the epicenter of injury, while microglia expressing lower Mac2 but higher CX3CR1 distribute to the edges of lesion. Myelin debris at the lesion site switches BMDMs

Errors-in-variables regression is the study of the association between covariates and responses where covariates are observed with errors. In this paper, we consider the estimation of multivariate regression functions for dependent data with errors in covariates. Nonparametric deconvolution technique is used to account for errors-in-variables. The asymptotic behavior of regression estimators depends on the smoothness of the error distributions, which are characterized as either ordinarily smooth or super smooth. Asymptotic normality is established for both strongly mixing and -mixing processes, when the error distribution function is either ordinarily smooth or super smooth.

We develop a specification test for the transition density of a discretely sampled continuous-time jump-diffusion process, based on a comparison of a nonparametric estimate of the transition density or distribution function with their corresponding parametric counterparts assumed by the null hypothesis. As a special case, our method applies to pure diffusions. We provide a direct comparison of the two densities for an arbitrary specification of the null parametric model using three different discrepancy measures between the null and alternative transition density and distribution functions. We establish the asymptotic null distributions of proposed test statistics and compute their power functions. We investigate the finite-sample properties through simulations and compare them with those of other tests. This article has supplementary material online.