In this paper, we establish the global C^{2,α} and W^{2,p} regularity for the Monge-Amp`ere equation det D^2u = f subject to boundary condition Du(Ω) = Ω^∗, where Ω and Ω^∗ are bounded convex domains in the Euclidean space R^n with C^{1,1} boundaries, and f is a Ho ̈lder continuous function. This boundary value problem arises naturally in optimal transportation and many other applications.