Adult stem cells, which exist throughout the body, multiply by cell division to replenish dying cells or to promote regeneration to repair damaged tissues. To perform these functions during the lifetime of organs or tissues, stem cells need to maintain their populations in a faithful distribution of their epigenetic states, which are suscepti- ble to stochastic fluctuations during each cell division, unexpected injury, and potential genetic mutations that occur during many cell divisions. However, it remains unclear how the three processes of differentiation, proliferation, and apoptosis in regulating stem cells collectively manage these challenging tasks. Here, without consid- ering molecular details, we propose a genetic optimal control model for adult stem cell regeneration that includes the three fundamental processes, along with cell division and adaptation based on differ- ential fitnesses of phenotypes. In the model, stem cells with a distri- bution of epigenetic states are required to maximize expected performance after each cell division. We show that heteroge- neous proliferation that depends on the epigenetic states of stem cells can improve the maintenance of stem cell distributions to create balanced populations. A control strategy during each cell division leads to a feedback mechanism involving heterogeneous proliferation that can accelerate regeneration with less fluctuation in the stem cell population. When mutation is allowed, apoptosis evolves to maximize the performance during homeostasis after multiple cell divisions. The overall results highlight the importance of cross-talk between genetic and epigenetic regulation and the performance objectives during homeostasis in shaping a desirable heterogeneous distribution of stem cells in epigenetic states.

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This paper is devoted to studying an augmented Lagrangian method for solving a class of manifold optimization problems, which have nonsmooth objective functions and non-negative constraints. Under the constant positive linear dependence condition on manifolds, we show that the proposed method converges to a stationary point of the nonsmooth manifold optimization problem. Moreover, we propose a globalized semismooth Newton method to solve the augmented Lagrangian subproblem on manifolds efficiently. The local superlinear convergence of the manifold semismooth Newton method is also established under some suitable conditions. We also prove that the semismoothness on submanifolds can be inherited from that in the ambient manifold. Finally, numerical experiments on compressed modes and (constrained) sparse principal component analysis illustrate the advantages of the proposed method.

The aim of this paper is to provide a fast and efficient procedure for (real-time) target identification in imaging based on matching on a dictionary of precomputed generalized polarization tensors (GPTs). The approach is based on some important properties of the GPTs and new invariants. A new shape representation is given and numerically tested in the presence of measurement noise. The stability and resolution of the proposed identification algorithm is numerically quantified. We compare the proposed GPT-based shape representation with a moment-based one.