We study the spectral geometric properties of the scalar Laplace–Beltrami operator associated to the Weil–Petersson metric $g_{WP}$ on $\mathcal{M}_{\gamma}$ , the Riemann moduli space of surfaces of genus  $\gamma>1$. This space has a singular compactification with respect to $g_{WP}$, and this metric has crossing cusp-edge singularities along a finite collection of simple normal crossing divisors. We prove first that the scalar Laplacian is essentially self-adjoint, which then implies that its spectrum is discrete.

Macrophages play an important role in the inflammatory responses involved with spinal cord injury (SCI). We have previously demonstrated that infiltrated bone marrow-derived macrophages (BMDMs) engulf myelin debris, forming myelin-laden macrophages (mye-M). These mye-M promote disease progression through their pro-inflammatory phenotype, enhanced neurotoxicity, and impaired phagocytic capacity for apoptotic cells. We thus hypothesize that the excessive accumulation of mye-M is the root of secondary injury, and that targeting mye-M represents an efficient strategy to improve the local inflammatory microenvironment in injured spinal cords and to further motor neuron function recovery. In this study, we administer murine embryonic stem cell conditioned media (ESC-M) as a cell-free stem cell based therapy to treat a mouse model of SCI. We showed that BMDMs, but not microglial cells, engulf myelin debris generated at the injury site. Phagocytosis of myelin debris leads to the formation of mye-M in the injured spinal cord, which are surrounded by activated microglia cells. These mye-M are pro-inflammatory and lose the normal macrophage phagocytic capacity for apoptotic cells. We therefore focus on how to trigger lipid efflux from mye-M and thus restore their function. Using ESC-M as an immune modulating treatment for inflammatory damage after SCI, we rescued mye-M function and improved functional locomotor recovery. ESC-M treatment on mye-M resulted in improved exocytosis of internalized lipids and a normal capacity for apoptotic cell phagocytosis. Furthermore, when ESC-M was administered

In this paper we introduce a path complex that can be regarded as a generalization of the notion of a simplicial complex. The main motivation for considering path complexes comes from directed graphs (digraphs). We obtain a new notion of the path homology and cohomology of a digraph.

We use a differential form cohomology theory on transitive digraphs to give a new proof of a theorem of Gerstenhaber and Schack about isomorphism between simplicial cohomology and Hochschild cohomology of a certain algebra associated with the simplicial complex.

Let X be a compact Khler manifold and X a subvariety of X with higher co-dimension. The aim is to study complete constant scalar curvature Khler metrics on non-compact Khler manifold X with Poincar--Mok--Yau asymptotic property (see Definition\ref {def}). In this paper, the methods of Calabi's ansatz and the moment construction are used to provide some special examples of such metrics.