A variational formula for the Lutwak affine surface areas j of convex bodies in Rn is established when 1 ≤ j ≤ n − 1. By using introduced new ellipsoids associated with projection functions of convex bodies, we prove a sharp isoperimetric inequality for j , which opens up a new passage to attack the longstanding Lutwak conjecture in convex geometry.

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Let M be a complete non-compact Riemannian manifold whose sectional curvature is bounded between two constants-k and K. Then one expects that the heat diffusion in such a manifold behaves like the heat diffusion in Euclidean space. The purpose of this paper is to give a justi-fication of such a statement.

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Single-cell (sc)RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these data, however, requires kinetic models capable of unveiling governing regulatory functions. Here, we introduce an analytical framework dynamo (https://github.com/aristoteleo/dynamo-release), which infers absolute RNA velocity, reconstructs continuous vector fields that predict cell fates, employs differential geometry to extract underlying regulations, and ultimately predicts optimal reprogramming paths and perturbation outcomes. We highlight dynamo’s power to overcome fundamental limitations of conventional splicing-based RNA velocity analyses to enable accurate velocity estimations on a metabolically labeled human hematopoiesis scRNA-seq dataset. Furthermore, differential geometry analyses reveal mechanisms driving early megakaryocyte appearance and elucidate asymmetrical regulation within the PU.1-GATA1 circuit. Leveraging the least-action-path method, dynamo accurately predicts drivers of numerous hematopoietic transitions. Finally, in silico perturbations predict cell-fate diversions induced by gene perturbations. Dynamo, thus, represents an important step in advancing quantitative and predictive theories of cell-state transitions.