Portfolio allocation with gross-exposure constraint is an effective method to increase the efficiency and stability of portfolios selection among a vast pool of assets, as demonstrated by Fan, Zhang, and Yu. The required high-dimensional volatility matrix can be estimated by using high-frequency financial data. This enables us to better adapt to the local volatilities and local correlations among a vast number of assets and to increase significantly the sample size for estimating the volatility matrix. This article studies the volatility matrix estimation using high-dimensional, high-frequency data from the perspective of portfolio selection. Specifically, we propose the use of pairwise-refresh time and all-refresh time methods based on the concept of refresh time proposed by Barndorff-Nielsen, Hansen, Lunde, and Shephard for the estimation of vast covariance matrix and compare their merits in the portfolio selection. We

Children learn effortlessly by example and exhibit a remarkable capacity of generalization. The field of machine learning, on the other hand, stumbles along clumsily in search of algorithms and methods, but nothing available today comes even close to an average two-year-old toddler. So, modestly, we present some results on one of the main paradigms in machine learningnearest neighbor methods. Rummaging through old data for the closest match seems like a sensible thing to do, and that primitive idea can be formalized and made rigorous. In the field of nonparametric statistics, where one is concerned with the estimation of densities, distribution functions, regression functions, and functionals, the nearest neighbor family of methods was in the limelight from the very beginning and has achieved some level of maturity.

Value at Risk (VaR) is a fundamental tool for managing market risks. It measures the worst loss to be expected of a portfolio over a given time horizon under normal market conditions at a given confidence level. Calculation of VaR frequently involves estimating the volatility of return processes and quantiles of standardized returns. In this paper, several semiparametric techniques are introduced to estimate the volatilities of the market prices of a portfolio. In addition, both parametric and nonparametric techniques are proposed to estimate the quantiles of standardized return processes. The newly proposed techniques also have the flexibility to adapt automatically to the changes in the dynamics of market prices over time. Their statistical efficiencies are studied both theoretically and empirically. The combination of newly proposed techniques for estimating volatility and standardized quantiles yields several new

The varying coefficient model is an important class of nonparametric statistical model, which allows us to examine how the effects of covariates vary with exposure variables. When the number of covariates is large, the issue of variable selection arises. In this article, we propose and investigate marginal nonparametric screening methods to screen variables in sparse ultra-high-dimensional varying coefficient models. The proposed nonparametric independence screening (NIS) selects variables by ranking a measure of the nonparametric marginal contributions of each covariate given the exposure variable. The sure independent screening property is established under some mild technical conditions when the dimensionality is of nonpolynomial order, and the dimensionality reduction of NIS is quantified. To enhance the practical utility and finite sample performance, two data-driven iterative NIS (INIS) methods are

LPS is a main causative agent of septic shock. There is a lack of effective therapies. In vitro studies have shown that uptake of apoptotic cells actively inhibits the secretion by activated macrophages (M) of proinflammatory mediators such as TNF- and that such uptake increases the antiinflammatory and immunosuppressive cytokine TGF-. We therefore investigated the protective effect of apoptotic cells against LPS-induced endotoxic shock in mice. The current report is the first study to demonstrate that administration of apoptotic cells can protect mice from LPS-induced death, even when apoptotic cells were administered 24 h after LPS challenge. The beneficial effects of administration of apoptotic cells included 1) reduced circulating proinflammatory cytokines, 2) suppression of polymorphonuclear neutrophil infiltration in target organs, and 3) decreased serum LPS levels. LPS can quickly bind to apoptotic cells