A popular approach to solving the nonlinear complementarity problem (NCP) is to reformulate it as the global minimization of a certain merit function over ^<i>n</i>. A popular choice of the merit function is the squared norm of the Fischer-Burmeister function, shown to be smooth over ^<i>n</i> and, for monotone NCP, each stationary point is a solution of the NCP. This merit function and its analysis were subsequently extended to the semidefinite complementarity problem (SDCP), although only differentiability, not continuous differentiability, was established. In this paper, we extend this merit function and its analysis, including continuous differentiability, to the second-order cone complementarity problem (SOCCP). Although SOCCP is reducible to a SDCP, the reduction does not allow for easy translation of the analysis from SDCP to SOCCP. Instead, our analysis exploits

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Mean-Field Games are games with a continuum of players that incorporate the time-dimension through a control-theoretic approach. Recently, simpler approaches relying on the Best Reply Strategy have been proposed. They assume that the agents navigate their strategies towards their goal by taking the direction of steepest descent of their cost function (i.e. the opposite of the utility function). In this paper, we explore the link between Mean-Field Games and the Best Reply Strategy approach. This is done by introducing a Model Predictive Control framework, which consists of setting the Mean-Field Game over a short time interval which recedes as time moves on. We show that the Model Predictive Control offers a compromise between a possibly unrealistic Mean-Field Game approach and the sub-optimal Best Reply Strategy.

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Adult stem cells, which exist throughout the body, multiply by cell division to replenish dying cells or to promote regeneration to repair damaged tissues. To perform these functions during the lifetime of organs or tissues, stem cells need to maintain their populations in a faithful distribution of their epigenetic states, which are suscepti- ble to stochastic fluctuations during each cell division, unexpected injury, and potential genetic mutations that occur during many cell divisions. However, it remains unclear how the three processes of differentiation, proliferation, and apoptosis in regulating stem cells collectively manage these challenging tasks. Here, without consid- ering molecular details, we propose a genetic optimal control model for adult stem cell regeneration that includes the three fundamental processes, along with cell division and adaptation based on differ- ential fitnesses of phenotypes. In the model, stem cells with a distri- bution of epigenetic states are required to maximize expected performance after each cell division. We show that heteroge- neous proliferation that depends on the epigenetic states of stem cells can improve the maintenance of stem cell distributions to create balanced populations. A control strategy during each cell division leads to a feedback mechanism involving heterogeneous proliferation that can accelerate regeneration with less fluctuation in the stem cell population. When mutation is allowed, apoptosis evolves to maximize the performance during homeostasis after multiple cell divisions. The overall results highlight the importance of cross-talk between genetic and epigenetic regulation and the performance objectives during homeostasis in shaping a desirable heterogeneous distribution of stem cells in epigenetic states.