In these notes, we provide an introduction to the hemisphere partition function of 2d (2, 2) supersymmetric gauge theories, and discuss its relation to the “D-brane central charge” which were studied in superstring theory, in 2d supersymmetric quantum field theory, and in topological string theory. We also discuss relation to “macroscopic loop” in matrix models. They are mostly reviews of the work by the authors, but contains some new results such as the partition function for a rotated supersymmetry as well as the differential equations.