Let M and N be two compact complex manifolds. We show that if the tautological line bundle O_{T^∗}M(1) is not pseudo-effective and O_{T^∗}N(1) is nef, then there is no non-constant holomorphic map from M to N. In particular, we prove that any holomorphic map from a compact complex manifold M with RC-positive tangent bundle to a compact complex manifold N with nef cotangent bundle must be a constant map. As an application, we obtain that there is no non-constant holomorphic map from a compact Hermitian manifold with positive holomorphic sectional curvature to a Hermitian manifold with non-positive holomorphic bisectional curvature.

Let M be a compact Riemannian manifold, π : \tilde{M} → M be the universal covering and ω be a smooth 2-form on M with π^∗ω cohomologous to zero. Suppose the fundamental group π_1(M) satisfies certain radial quadratic (resp. linear) isoperimetric inequality, we show that there exists a smooth 1-form η on \tilde{M} of linear (resp. bounded) growth such that π^∗ω = dη. As applications, we prove that on a compact Kahler manifold (M,ω) with π^∗ω cohomologous to zero, if π_1(M) is CAT(0) or automatic (resp. hyperbolic), then M is Kahler non-elliptic (resp. Kahler hyperbolic) and the Euler characteristic (−1)^{dim_RM/2χ(M) ≥ 0 (resp. >0).

We define enlargeable length-structures on closed topological manifolds and then show that the connected sum of a closed n-manifold with an enlargeable Riemannian length-structure with an arbitrary closed smooth manifold carries no Riemannian metrics with positive scalar curvature. We show that closed smooth manifolds with a locally CAT(0)-metric which is strongly equivalent to a Riemannian metric are examples of closed manifolds with an enlargeable Riemannian length-structure. Moreover, the result is correct in arbitrary dimensions based on the main result of a recent paper by Schoen and Yau. We define the positive MV-scalar curvature on closed orientable topological manifolds and show the compactly enlargeable length-structures are the obstructions of its existence.